{"id":181767,"date":"2024-01-31T04:25:28","date_gmt":"2024-01-31T10:25:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/01\/u-of-t-researchers-ai-model-designs-proteins-to-deliver-gene-therapy"},"modified":"2024-01-31T04:25:28","modified_gmt":"2024-01-31T10:25:28","slug":"u-of-t-researchers-ai-model-designs-proteins-to-deliver-gene-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/01\/u-of-t-researchers-ai-model-designs-proteins-to-deliver-gene-therapy","title":{"rendered":"U of T researchers\u2019 AI model designs proteins to deliver gene therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/u-of-t-researchers-ai-model-designs-proteins-to-deliver-gene-therapy2.jpg\"><\/a><\/p>\n<p>University of Toronto Engineering researchers\u2019 AI model designs proteins to deliver gene therapy \u27a1\ufe0f<\/p>\n<hr>\n<p>Researchers at the University of Toronto used an artificial intelligence framework to redesign a crucial protein involved in the delivery of gene therapy.<\/p>\n<p>The study, <a href=\"https:\/\/www.nature.com\/articles\/s42256-023-00787-2\">published in <em>Nature Machine Intelligence<\/em><\/a>, describes new work optimizing proteins to mitigate immune responses, thereby improving the efficacy of gene therapy and reducing side effects.<\/p>\n<p>\u201cGene therapy holds immense promise, but the body\u2019s pre-existing immune response to viral vectors greatly hampers its success. Our research zeroes in on hexons, a fundamental protein in adenovirus vectors, which \u2013 but for the immune problem \u2013 hold huge potential for gene therapy,\u201d says <strong>Michael Garton<\/strong>, an assistant professor at the Institute of Biomedical Engineering in the Faculty of Applied Science &amp; Engineering.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Toronto Engineering researchers\u2019 AI model designs proteins to deliver gene therapy \u27a1\ufe0f Researchers at the University of Toronto used an artificial intelligence framework to redesign a crucial protein involved in the delivery of gene therapy. The study, published in Nature Machine Intelligence, describes new work optimizing proteins to mitigate immune responses, thereby improving [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-181767","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=181767"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181767\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=181767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=181767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=181767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}