{"id":181727,"date":"2024-01-30T18:22:51","date_gmt":"2024-01-31T00:22:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/01\/new-ai-model-designs-proteins-to-deliver-gene-therapy"},"modified":"2024-01-30T18:22:51","modified_gmt":"2024-01-31T00:22:51","slug":"new-ai-model-designs-proteins-to-deliver-gene-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/01\/new-ai-model-designs-proteins-to-deliver-gene-therapy","title":{"rendered":"New AI model designs proteins to deliver gene therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-ai-model-designs-proteins-to-deliver-gene-therapy2.jpg\"><\/a><\/p>\n<p>Researchers at the University of Toronto have used an artificial intelligence framework to redesign a crucial protein involved in the delivery of gene therapy.<\/p>\n<p>The study, <a href=\"https:\/\/www.nature.com\/articles\/s42256-023-00787-2\">published<\/a> in <i>Nature Machine Intelligence<\/i>, describes new work optimizing proteins to mitigate immune responses, thereby improving the efficacy of gene therapy and reducing side effects.<\/p>\n<p>\u201cGene therapy holds immense promise, but the body\u2019s pre-existing <a href=\"https:\/\/phys.org\/tags\/immune+response\/\" rel=\"tag\" class=\"\">immune response<\/a> to viral vectors greatly hampers its success. Our research zeroes in on hexons, a fundamental protein in adenovirus vectors, which\u2014but for the immune problem\u2014hold huge potential for gene therapy,\u201d says Michael Garton, an assistant professor at the Institute of Biomedical Engineering in the Faculty of Applied Science &amp; Engineering.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of Toronto have used an artificial intelligence framework to redesign a crucial protein involved in the delivery of gene therapy. The study, published in Nature Machine Intelligence, describes new work optimizing proteins to mitigate immune responses, thereby improving the efficacy of gene therapy and reducing side effects. \u201cGene therapy holds immense [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-181727","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=181727"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181727\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=181727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=181727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=181727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}