{"id":180725,"date":"2024-01-17T16:26:06","date_gmt":"2024-01-17T22:26:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/01\/nih-developed-hiv-antibodies-protect-animals-in-proof-of-concept-study"},"modified":"2024-01-17T16:26:06","modified_gmt":"2024-01-17T22:26:06","slug":"nih-developed-hiv-antibodies-protect-animals-in-proof-of-concept-study","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/01\/nih-developed-hiv-antibodies-protect-animals-in-proof-of-concept-study","title":{"rendered":"NIH-Developed HIV Antibodies Protect Animals in Proof-of-Concept Study"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nih-developed-hiv-antibodies-protect-animals-in-proof-of-concept-study2.jpg\"><\/a><\/p>\n<p>Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people. The antibodies\u2014a human broadly neutralizing antibody and two antibodies isolated from previously vaccinated monkeys\u2014target the fusion peptide, a site on an HIV surface protein that helps the virus fuse with and enter cells. The study, published in <em>Science Translational Medicine<\/em>, was led by the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.<\/p>\n<p>Antibodies that target the fusion peptide can neutralize diverse strains of HIV <em>in vitro<\/em>, that is, in a test tube or culture dish outside of a living organism. The NIAID VRC isolated a fusion peptide-directed human antibody, called VRC34.01, from a person living with HIV who donated blood samples for research. They also isolated two antibodies from rhesus macaques\u2014a species of monkey with immune systems like humans\u2019\u2014who previously had received a vaccine regimen designed to generate fusion peptide-directed antibodies. Demonstrating that these antibodies protect animals would validate the fusion peptide as a target for human vaccine design. SHIV challenge\u2014administering an infective dose of SHIV\u2014to rhesus macaques is a widely used animal model for assessing the performance of HIV antibodies and vaccines.<\/p>\n<p>In this study, rhesus macaques in each of four groups received a single intravenous infusion of one type of antibody\u2014a 2.5 or 10 mg\/kg of bodyweight dose of VRC34.01, or one of the two vaccine-elicited rhesus macaque antibodies\u2014and other monkeys received a placebo infusion. To determine the protective effect of the antibodies, each monkey was challenged five days after infusion with a strain of SHIV known to be sensitive to fusion peptide-directed antibodies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people. The antibodies\u2014a human broadly neutralizing antibody and two antibodies isolated from previously vaccinated monkeys\u2014target the fusion peptide, a site on an HIV surface protein that helps the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-180725","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/180725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=180725"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/180725\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=180725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=180725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=180725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}