{"id":180295,"date":"2024-01-11T15:24:29","date_gmt":"2024-01-11T21:24:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/01\/scientists-identify-how-dietary-restriction-slows-brain-aging-and-increases-lifespan"},"modified":"2024-01-11T15:24:29","modified_gmt":"2024-01-11T21:24:29","slug":"scientists-identify-how-dietary-restriction-slows-brain-aging-and-increases-lifespan","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/01\/scientists-identify-how-dietary-restriction-slows-brain-aging-and-increases-lifespan","title":{"rendered":"Scientists identify how dietary restriction slows brain aging and increases lifespan"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-identify-how-dietary-restriction-slows-brain-aging-and-increases-lifespan3.jpg\"><\/a><\/p>\n<p>Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck Institute for Research on Aging scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.<\/p>\n<p>\u201cWhen people restrict the amount of food that they eat, they typically think it might affect their <a href=\"https:\/\/medicalxpress.com\/tags\/digestive+tract\/\" rel=\"tag\" class=\"\">digestive tract<\/a> or fat buildup, but not necessarily about how it affects the brain,\u201d said Kenneth Wilson, Ph.D., Buck postdoc and first author of the study, <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-44343-3\">published in<\/a> <i>Nature Communications<\/i>. \u201cAs it turns out, this is a gene that is important in the brain.\u201d<\/p>\n<p>The team additionally demonstrated a detailed cellular mechanism of how <a href=\"https:\/\/medicalxpress.com\/tags\/dietary+restriction\/\" rel=\"tag\" class=\"\">dietary restriction<\/a> can delay aging and slow the progression of neurodegenerative diseases. The work, done in <a href=\"https:\/\/medicalxpress.com\/tags\/fruit+flies\/\" rel=\"tag\" class=\"\">fruit flies<\/a> and <a href=\"https:\/\/medicalxpress.com\/tags\/human+cells\/\" rel=\"tag\" class=\"\">human cells<\/a>, also identifies potential therapeutic targets to slow aging and age-related neurodegenerative diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck Institute for Research on Aging scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-180295","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/180295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=180295"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/180295\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=180295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=180295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=180295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}