{"id":179705,"date":"2024-01-03T07:23:12","date_gmt":"2024-01-03T13:23:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/01\/novel-switch-turns-genes-on-off-on-cue-a-promising-step-toward-safer-gene-therapy"},"modified":"2024-01-03T07:23:12","modified_gmt":"2024-01-03T13:23:12","slug":"novel-switch-turns-genes-on-off-on-cue-a-promising-step-toward-safer-gene-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/01\/novel-switch-turns-genes-on-off-on-cue-a-promising-step-toward-safer-gene-therapy","title":{"rendered":"Novel switch turns genes on\/off on cue, a promising step toward safer gene therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/novel-switch-turns-genes-on-off-on-cue-a-promising-step-toward-safer-gene-therapy2.jpg\"><\/a><\/p>\n<p>Just like a doctor adjusts the dose of a medication to the patient\u2019s needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window. Staying within the therapeutic window is important as too much of the protein could be toxic, and too little could result in a small or no therapeutic effect.<\/p>\n<p>Although the principle of <a href=\"https:\/\/phys.org\/tags\/therapeutic+window\/\" rel=\"tag\" class=\"\">therapeutic window<\/a> has been known for a long time, there has been no strategy to implement it safely, limiting the potential applications of gene therapy in the clinic.<\/p>\n<p>In their current study <a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01989-0\">published<\/a> in the journal <i>Nature Biotechnology<\/i>, researchers at Baylor College of Medicine report on a technology to effectively regulate gene expression, a promising solution to fill this gap in gene therapy clinical applications. A <a href=\"https:\/\/www.nature.com\/articles\/s41587-023-02020-2\">Research Briefing<\/a> on the breakthrough has been published in the same journal issue.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Just like a doctor adjusts the dose of a medication to the patient\u2019s needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window. Staying within the therapeutic window is important as too much of the protein [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-179705","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/179705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=179705"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/179705\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=179705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=179705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=179705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}