{"id":178785,"date":"2023-12-21T04:23:00","date_gmt":"2023-12-21T10:23:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/12\/new-treatment-reverses-alzheimers-disease-signs-improves-memory-function-in-preclinical-study"},"modified":"2023-12-21T04:23:00","modified_gmt":"2023-12-21T10:23:00","slug":"new-treatment-reverses-alzheimers-disease-signs-improves-memory-function-in-preclinical-study","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/12\/new-treatment-reverses-alzheimers-disease-signs-improves-memory-function-in-preclinical-study","title":{"rendered":"New treatment reverses Alzheimer\u2019s disease signs, improves memory function in preclinical study"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-treatment-reverses-alzheimers-disease-signs-improves-memory-function-in-preclinical-study3.jpg\"><\/a><\/p>\n<p>A \u201cchaperone\u201d molecule that slows the formation of certain proteins reversed disease signs, including memory impairment, in a mouse model of Alzheimer\u2019s disease, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.<\/p>\n<p>In the study, published in <a href=\"https:\/\/agingcelljournal.org\/Archive\/Volume3\/20230017\/\">Aging Biology<\/a>, researchers examined the effects of a compound called 4-phenylbutyrate (PBA), a fatty-acid molecule known to work as a \u201cchemical chaperone\u201d that inhibits <a href=\"https:\/\/medicalxpress.com\/tags\/protein+accumulation\/\" rel=\"tag\" class=\"\">protein accumulation<\/a>. In mice that model Alzheimer\u2019s disease, injections of PBA helped to restore signs of normal proteostasis (the protein regulation process) in the animals\u2019 brains while also dramatically improving their performance on a standard memory test, even when administered late in the disease course.<\/p>\n<p>\u201cBy generally improving neuronal and cellular health, we can mitigate or delay <a href=\"https:\/\/medicalxpress.com\/tags\/disease+progression\/\" rel=\"tag\" class=\"\">disease progression<\/a>,\u201d said study senior author Nirinjini Naidoo, Ph.D., a research associate professor of Sleep Medicine. \u201cIn addition, reducing proteotoxicity\u2014 <a href=\"https:\/\/medicalxpress.com\/tags\/irreparable+damage\/\" rel=\"tag\" class=\"\">irreparable damage<\/a> to the cell that is caused by an accumulation of impaired and misfolded proteins\u2014can help improve some previously lost brain functions.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A \u201cchaperone\u201d molecule that slows the formation of certain proteins reversed disease signs, including memory impairment, in a mouse model of Alzheimer\u2019s disease, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania. In the study, published in Aging Biology, researchers examined the effects of a compound called [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,269,47],"tags":[],"class_list":["post-178785","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/178785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=178785"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/178785\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=178785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=178785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=178785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}