{"id":178588,"date":"2023-12-18T12:25:48","date_gmt":"2023-12-18T18:25:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/12\/improving-gut-health-with-microbiome-and-probiotics"},"modified":"2023-12-18T12:25:48","modified_gmt":"2023-12-18T18:25:48","slug":"improving-gut-health-with-microbiome-and-probiotics","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/12\/improving-gut-health-with-microbiome-and-probiotics","title":{"rendered":"Improving Gut Health with Microbiome and Probiotics"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/th3UwC10EZU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>View show notes here: <a href=\"https:\/\/bit.ly\/3GJjQKz\">https:\/\/bit.ly\/3GJjQKz<\/a> Become a member to receive exclusive content: <a href=\"https:\/\/peterattiamd.com\/subscribe\/\">https:\/\/peterattiamd.com\/subscribe\/<\/a> Sign up to receive Peter\u2019s email newsletter: <a href=\"https:\/\/peterattiamd.com\/newsletter\/\">https:\/\/peterattiamd.com\/newsletter\/<\/a> Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: 0:00:00 \u2014 Intro 0:00:34 \u2014 Colleen\u2019s background and current focus 0:03:08 \u2014 The basics of the microbiome 0:12:37 \u2014 The study of the human microbiome 0:17:42 \u2014 Categories of bacteria, and the implications on health of the rapid evolution of bacteria 0:27:51 \u2014 Methods for measuring and understanding the microbiome, and key indicators of microbiome health 0:39:52 \u2014 The important role of fiber for promoting gut health through the production of butyrate 0:47:21 \u2014 The case for manipulating gut bacteria via fecal microbiota transplant (FMT) 0:53:25 \u2014 Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome\u2019s diversity and function 0:59:16 \u2014 Factors that influence the vaginal microbiom 1:03:46 \u2014 The effect of gut microbes on obesity and challenges with fecal transplants in people 1:06:25 \u2014 Beneficial strains of gut bacteria and strains commonly found in probiotics 1:16:35 \u2014 The difference between a probiotic and prebiotic, and how CFUs are a measure of the \u201cactive ingredient\u201d 1:21:47 \u2014 Considerations about how probiotic strains are produced, and more on the meaning of CFU 1:31:12 \u2014 Mitigating the effect of antibiotics on the microbiome 1:39:58 \u2014 What do we know about the effect of artificial sweeteners on the gut microbiome? 1:47:02 \u2014 Why Akkermansia is a keystone strain with implications for metabolic health and an individual\u2019s response to dietary interventions 1:58:14 \u2014 The essential steps necessary to develop a robust probiotic for optimal health support 2:01:45 \u2014 How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more 2:22:46 \u2014 Pendulum Therapeutics\u2019 commitment to rigorous product develop 2:29:54 \u2014 Details about the probiotic \u201cGlucose Control\u201d and other probiotics developed by Pendulum Therapeutics 2:38:43 \u2014 Further studies of Akkermansia that have been proposed or are underway \u2014\u2014\u2013 About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer\u2019s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>View show notes here: https:\/\/bit.ly\/3GJjQKz Become a member to receive exclusive content: https:\/\/peterattiamd.com\/subscribe\/ Sign up to receive Peter\u2019s email newsletter: https:\/\/peterattiamd.com\/newsletter\/ Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into [\u2026]<\/p>\n","protected":false},"author":716,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,385,269,47],"tags":[],"class_list":["post-178588","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-evolution","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/178588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/716"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=178588"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/178588\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=178588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=178588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=178588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}