{"id":177610,"date":"2023-12-07T08:25:20","date_gmt":"2023-12-07T14:25:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/12\/how-3d-changes-in-the-genome-turned-sharks-into-skates"},"modified":"2023-12-07T08:25:20","modified_gmt":"2023-12-07T14:25:20","slug":"how-3d-changes-in-the-genome-turned-sharks-into-skates","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/12\/how-3d-changes-in-the-genome-turned-sharks-into-skates","title":{"rendered":"How 3D Changes in the Genome Turned Sharks Into Skates"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-3d-changes-in-the-genome-turned-sharks-into-skates2.jpg\"><\/a><\/p>\n<p>However, when major genome rearrangements occur \u2014 like the ones that the team was seeing in the skate\u2019s DNA \u2014 boundaries can be lost, and the relative positions of genes on chromosomes can change. As a result, \u201csome enhancers can provide instructions to the wrong gene,\u201d explained <a href=\"https:\/\/www.mdc-berlin.de\/lupianez\">Dario Lupi\u00e1\u00f1ez<\/a>, an evolutionary biologist at the Max Delbr\u00fcck Center in Berlin and one of the senior authors of the study.<\/p>\n<p>It seemed possible that the changes in the 3D architecture of the skate genome might have disrupted the ancient blocks of genes the skates inherited from their sharklike ancestors, affecting the genes\u2019 function. \u201cWe were trying to look at whether some genome rearrangements in the little skate actually break these blocks,\u201d said <a href=\"https:\/\/www.ucl.ac.uk\/biosciences\/people\/dr-ferdinand-marletaz\">Ferdinand Marl\u00e9taz<\/a>, a genomicist at University College London and co-first author of the study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>However, when major genome rearrangements occur \u2014 like the ones that the team was seeing in the skate\u2019s DNA \u2014 boundaries can be lost, and the relative positions of genes on chromosomes can change. As a result, \u201csome enhancers can provide instructions to the wrong gene,\u201d explained Dario Lupi\u00e1\u00f1ez, an evolutionary biologist at the Max [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-177610","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/177610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=177610"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/177610\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=177610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=177610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=177610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}