{"id":177177,"date":"2023-12-01T08:25:53","date_gmt":"2023-12-01T14:25:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/12\/molecular-movie-captures-dna-repair-from-start-to-finish"},"modified":"2023-12-01T08:25:53","modified_gmt":"2023-12-01T14:25:53","slug":"molecular-movie-captures-dna-repair-from-start-to-finish","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/12\/molecular-movie-captures-dna-repair-from-start-to-finish","title":{"rendered":"Molecular movie captures DNA repair from start to finish"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/molecular-movie-captures-dna-repair-from-start-to-finish.jpg\"><\/a><\/p>\n<p>An international team of researchers has used time-resolved ultrafast crystallography to follow the progress of DNA repair by a photolyase enzyme. The work is \u2018the first structural characterisation of a full enzyme reaction cycle,\u2019 says Manuel Maestre-Reyna, who led the research.<\/p>\n<p>Photolyases repair DNA damage caused by ultraviolet light in bacteria, fungi, plants and some animals including marsupials. Humans and other mammals don\u2019t contain these enzymes, but we too incur light-induced damage. One common outcome is the formation of cyclobutane pyrimidine dimers (CPDs), where two adjacent pyrimidine bases (thymine or cytosine) fuse together via a four-membered cyclobutane ring. \u2018CPD formation is the main cause of skin cancer, and sunburnt skin always contains CPD lesions\u2019, says Maestre-Reyna, a biochemist at the Institute of Biological Chemistry in Taipei, Taiwan.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international team of researchers has used time-resolved ultrafast crystallography to follow the progress of DNA repair by a photolyase enzyme. The work is \u2018the first structural characterisation of a full enzyme reaction cycle,\u2019 says Manuel Maestre-Reyna, who led the research. Photolyases repair DNA damage caused by ultraviolet light in bacteria, fungi, plants and some [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-177177","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/177177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=177177"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/177177\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=177177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=177177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=177177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}