{"id":176798,"date":"2023-11-26T08:29:03","date_gmt":"2023-11-26T14:29:03","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/11\/examining-the-biodistribution-and-function-of-polymer-dna-origami-nanostructures"},"modified":"2023-11-26T08:29:03","modified_gmt":"2023-11-26T14:29:03","slug":"examining-the-biodistribution-and-function-of-polymer-dna-origami-nanostructures","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/11\/examining-the-biodistribution-and-function-of-polymer-dna-origami-nanostructures","title":{"rendered":"Examining the biodistribution and function of polymer-DNA origami nanostructures"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/examining-the-biodistribution-and-function-of-polymer-dna-origami-nanostructures2.jpg\"><\/a><\/p>\n<p>The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-46351-1\">study<\/a> in <i>Scientific Reports<\/i>, Noah Joseph, and a team of biotechnology and nanoscience scientists in Israel, describe a nanoscale agent developed from a coupled polymer-DNA origami hybrid capable of exhibiting stability in serum and slow diffusion through tissues.<\/p>\n<p>By coupling to fragments of polyethylene glycol through polyamine <a href=\"https:\/\/phys.org\/tags\/electrostatic+interactions\/\" rel=\"tag\" class=\"\">electrostatic interactions<\/a>, the team noted marked stability of the agents in vivo, where more than 90% of the constituents maintained structural integrity for five days after subcutaneous injection.<\/p>\n<p>The findings highlight the polymer-DNA hybrid nanostructures as viable pharmacological agents that can enter mainstream technologies, including their use as <a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/immunotherapy\/monoclonal-antibodies\">monoclonal antibodies<\/a> for drug activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new study in Scientific Reports, Noah Joseph, and a team of biotechnology and nanoscience scientists in Israel, describe a nanoscale agent developed from a coupled polymer-DNA origami hybrid capable of exhibiting [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-176798","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=176798"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176798\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=176798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=176798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=176798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}