{"id":176434,"date":"2023-11-21T13:24:26","date_gmt":"2023-11-21T19:24:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/11\/proteins-predict-signs-of-alzheimers-disease"},"modified":"2023-11-21T13:24:26","modified_gmt":"2023-11-21T19:24:26","slug":"proteins-predict-signs-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/11\/proteins-predict-signs-of-alzheimers-disease","title":{"rendered":"Proteins Predict Signs of Alzheimer\u2019s Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/proteins-predict-signs-of-alzheimers-disease2.jpg\"><\/a><\/p>\n<p>Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer\u2019s disease and neurodegeneration, cross-sectional proteomic analyses showed.<\/p>\n<p>Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic protein (GFAP, a measure of astrogliosis), even in people without cardiovascular or kidney disease, reported Keenan Walker, PhD, of the National Institute on Aging in Baltimore, and co-authors.<\/p>\n<p>Proteomic indicators of body fat percentage, lean body mass, and visceral fat also were tied to p-tau181, NfL, and GFAP, Walker and colleagues wrote in the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ana.26817\" target=\"_blank\"><em>Annals of Neurology<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer\u2019s disease and neurodegeneration, cross-sectional proteomic analyses showed. Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic [\u2026]<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-176434","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=176434"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176434\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=176434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=176434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=176434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}