{"id":176399,"date":"2023-11-20T17:26:01","date_gmt":"2023-11-20T23:26:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/11\/gls1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders"},"modified":"2023-11-20T17:26:01","modified_gmt":"2023-11-20T23:26:01","slug":"gls1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/11\/gls1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders","title":{"rendered":"GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gls1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders2.jpg\"><\/a><\/p>\n<p>Year 2021 <span class=\"wp-smiley emoji emoji-face_with_colon_three\" title=\":3\">face_with_colon_three<\/span> <\/p>\n<hr>\n<p>Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called \u201ccellular senescence,\u201d a permanent cell cycle arrest resulting from multiple stresses.<\/p>\n<p>A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT), and co-researchers have identified an inhibitor of the glutamate metabolic enzyme GLS1so that its administration selectively eliminates senescent cells in vivo.<\/p>\n<p>They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and NASH. The results of this research were published in \u201c<em>Science<\/em>\u201d on January 15, 2021.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Year 2021 face_with_colon_three Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called \u201ccellular senescence,\u201d a permanent cell cycle arrest resulting from multiple stresses. A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-176399","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=176399"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176399\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=176399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=176399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=176399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}