{"id":176189,"date":"2023-11-17T08:23:43","date_gmt":"2023-11-17T14:23:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/11\/discovery-of-an-antibody-that-stimulates-the-immune-system-to-eliminate-cancer-cells"},"modified":"2023-11-17T08:23:43","modified_gmt":"2023-11-17T14:23:43","slug":"discovery-of-an-antibody-that-stimulates-the-immune-system-to-eliminate-cancer-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/11\/discovery-of-an-antibody-that-stimulates-the-immune-system-to-eliminate-cancer-cells","title":{"rendered":"Discovery of an antibody that stimulates the immune system to eliminate cancer cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/discovery-of-an-antibody-that-stimulates-the-immune-system-to-eliminate-cancer-cells3.jpg\"><\/a><\/p>\n<p>Major work led by Dr. Andr\u00e9 Veillette\u2019s team at the Institut de recherches cliniques de Montr\u00e9al (IRCM), in collaboration with a group of researchers, and just <a href=\"https:\/\/www.nature.com\/articles\/s41590-023-01671-2\">published<\/a> in <i>Nature Immunology<\/i>, managed to identify a previously unknown molecular action that prevents phagocytosis, which is a process that promotes the immune system\u2019s response to cancer. A <a href=\"https:\/\/www.nature.com\/articles\/s41590-023-01673-0\">Research Briefing<\/a> on the work done by the team has been published in the same journal.<\/p>\n<p>Macrophages are cells of the immune system. One of the roles of <a href=\"https:\/\/medicalxpress.com\/tags\/macrophages\/\" rel=\"tag\" class=\"\">macrophages<\/a> is to engulf, or \u201ceat,\u201d cells that are defective or dangerous, including cancer cells. This process is named phagocytosis. Macrophages can be called into action to eliminate cancer cells. However, this capacity is often defective, because macrophages are put in a state of dormancy by the cancer cells.<\/p>\n<p>This is in part because a particular molecule called CD47 is often over-abundant on cancer cells. CD47 prevents phagocytosis by triggering a molecule or \u201creceptor\u201d on macrophages named SIRP\u03b1. Agents that block the ability of CD47 to trigger SIRP\u03b1 have shown promising results for treating cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Major work led by Dr. Andr\u00e9 Veillette\u2019s team at the Institut de recherches cliniques de Montr\u00e9al (IRCM), in collaboration with a group of researchers, and just published in Nature Immunology, managed to identify a previously unknown molecular action that prevents phagocytosis, which is a process that promotes the immune system\u2019s response to cancer. A Research [\u2026]<\/p>\n","protected":false},"author":579,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-176189","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/579"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=176189"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/176189\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=176189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=176189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=176189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}