{"id":175105,"date":"2023-10-28T01:22:42","date_gmt":"2023-10-28T06:22:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/10\/rice-sized-device-tests-brain-tumors-drug-responses-during-surgery"},"modified":"2023-10-28T01:22:42","modified_gmt":"2023-10-28T06:22:42","slug":"rice-sized-device-tests-brain-tumors-drug-responses-during-surgery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/10\/rice-sized-device-tests-brain-tumors-drug-responses-during-surgery","title":{"rendered":"Rice-Sized Device Tests Brain Tumor\u2019s Drug Responses During Surgery"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/rice-sized-device-tests-brain-tumors-drug-responses-during-surgery2.jpg\"><\/a><\/p>\n<p>Scientists have made remarkable progress in understanding the underlying changes that make cancer grow and have applied this knowledge to develop and guide targeted treatment approaches to vastly improve outcomes for people with many cancer types. And yet treatment progress for people with brain tumors known as gliomas\u2014including the most aggressive glioblastomas\u2014has remained slow. One reason is that doctors lack tests that reliably predict which among many therapeutic options will work best for a given tumor.<\/p>\n<p>Now an NIH-funded team has developed a miniature device with the potential to change this for the approximately 25,000 people diagnosed with brain cancers in the U.S. each year [1]. When implanted into cancerous brain tissue during surgery, the rice-sized drug-releasing device can simultaneously conduct experiments to measure a tumor\u2019s response to more than a dozen drugs or drug combinations. What\u2019s more, a small clinical trial reported in <em>Science Translational Medicine<\/em> offers the first evidence in people with gliomas that these devices can safely offer unprecedented insight into tumor-specific drug responses [2].<\/p>\n<p>These latest findings come from a Brigham and Women\u2019s Hospital, Boston, team led by Pierpaolo Peruzzi and Oliver Jonas. They recognized that drug-screening studies conducted in cells or tissue samples in the lab too often failed to match what happens in people with gliomas undergoing cancer treatment. Wide variation within individual brain tumors also makes it hard to predict a tumor\u2019s likely response to various treatment options.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have made remarkable progress in understanding the underlying changes that make cancer grow and have applied this knowledge to develop and guide targeted treatment approaches to vastly improve outcomes for people with many cancer types. And yet treatment progress for people with brain tumors known as gliomas\u2014including the most aggressive glioblastomas\u2014has remained slow. One [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-175105","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/175105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=175105"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/175105\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=175105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=175105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=175105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}