{"id":174627,"date":"2023-10-23T16:25:56","date_gmt":"2023-10-23T21:25:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/10\/potential-therapeutic-treatment-for-kidney-failure-in-children-discovered"},"modified":"2023-10-23T16:25:56","modified_gmt":"2023-10-23T21:25:56","slug":"potential-therapeutic-treatment-for-kidney-failure-in-children-discovered","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/10\/potential-therapeutic-treatment-for-kidney-failure-in-children-discovered","title":{"rendered":"Potential Therapeutic Treatment for Kidney Failure in Children Discovered"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/potential-therapeutic-treatment-for-kidney-failure-in-children-discovered.jpg\"><\/a><\/p>\n<p>An international team of researchers led by the University of Bristol report they have discovered a potential treatment for the world\u2019s leading cause of kidney failure in children needing dialysis.<\/p>\n<p>The findings are published in <em>Med<\/em> in an article titled, \u201c<a href=\"https:\/\/www.cell.com\/med\/fulltext\/S2666-6340(23)00289-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666634023002891%3Fshowall%3Dtrue\">Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation<\/a>.\u201d<\/p>\n<p>\u201cThe most common cause of kidney failure in children is due to toxin-producing bacteria that enter the circulation through the gut resulting in a disease called hemolytic uremic syndrome (HUS),\u201d wrote the researchers. \u201cThis commonly requires kidney dialysis, with approximately 5% of children developing life-long kidney failure or dying. It has been unclear why this toxin has a predilection for the kidney and what its mechanism of action is. This study shows the kidney podocyte cell is an important target of the toxin and signals to blood vessels through cellular crosstalk, causing complement activation and HUS.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international team of researchers led by the University of Bristol report they have discovered a potential treatment for the world\u2019s leading cause of kidney failure in children needing dialysis. The findings are published in Med in an article titled, \u201cShiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.\u201d \u201cThe most [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-174627","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/174627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=174627"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/174627\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=174627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=174627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=174627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}