{"id":174325,"date":"2023-10-16T23:23:48","date_gmt":"2023-10-17T04:23:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/10\/thousands-of-organisms-possess-dna-editing-enzyme-fanzor"},"modified":"2023-10-16T23:23:48","modified_gmt":"2023-10-17T04:23:48","slug":"thousands-of-organisms-possess-dna-editing-enzyme-fanzor","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/10\/thousands-of-organisms-possess-dna-editing-enzyme-fanzor","title":{"rendered":"Thousands of Organisms Possess DNA-Editing Enzyme Fanzor"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/thousands-of-organisms-possess-dna-editing-enzyme-fanzor.jpg\"><\/a><\/p>\n<p>In a new study, Abudayyeh and Gootenberg led a team of scientists on a quest to identify and characterize Fanzor enyzmes in large-scale genetic databases. Their genetic mining venture, published in <a href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciadv.adk0171\" target=\"_blank\"><i>Science Advances<\/i><\/a>, outlines the discovery of over 3,600 Fanzors in eukaryotes, including algae, snails, amoebas and the viruses that infect them.<\/p>\n<p><b><b>Fanzors evolved new features to survive and thrive in eukaryotes <\/b><\/b><\/p>\n<p>Five distinct families of Fanzors could be identified from the study data. By comparing the biological makeup of these families, Abudayyeh and colleagues could track their evolutionary history. Fanzors most likely evolved from proteins called TnpB, which are encoded in transposons \u2013 mobile genetic elements often nicknamed \u201cjumping genes\u201d. In <i>Nature,<\/i> the McGovern team hypothesized that the <i>TnpB <\/i>gene may have \u201cjumped\u201d from bacteria to eukaryotes in a genetic \u201cshuffling\u201d many years ago. Abudayyeh and Gootenburg\u2019s new study and genetic tracing implies that this event likely occurred several times, with Fanzors \u201cjumping\u201d from viruses and symbiotic bacteria. Their analyses also suggest that once these genes had made their way into eukaryotes, they evolved new features that promoted their survival, including the ability to enter a cell\u2019s nucleus and access its DNA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new study, Abudayyeh and Gootenberg led a team of scientists on a quest to identify and characterize Fanzor enyzmes in large-scale genetic databases. Their genetic mining venture, published in Science Advances, outlines the discovery of over 3,600 Fanzors in eukaryotes, including algae, snails, amoebas and the viruses that infect them. Fanzors evolved new [\u2026]<\/p>\n","protected":false},"author":609,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-174325","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/174325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/609"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=174325"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/174325\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=174325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=174325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=174325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}