{"id":173216,"date":"2023-10-01T02:22:34","date_gmt":"2023-10-01T07:22:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/10\/potential-new-treatment-target-for-metastatic-cancer-identified"},"modified":"2023-10-01T02:22:34","modified_gmt":"2023-10-01T07:22:34","slug":"potential-new-treatment-target-for-metastatic-cancer-identified","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/10\/potential-new-treatment-target-for-metastatic-cancer-identified","title":{"rendered":"Potential New Treatment Target for Metastatic Cancer Identified"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/potential-new-treatment-target-for-metastatic-cancer-identified.jpg\"><\/a><\/p>\n<p>In a recent study led by Lei Jiang, Ph.D., an assistant professor of molecular and cellular endocrinology, a team of researchers from City of Hope and the University of Texas Southwestern Medical Center, found a potential new target for treating patients with metastatic cancer. Their findings were published in the August 29 issue of the journal <i>Cell Rep <\/i>orts.<\/p>\n<p>The goal of the team\u2019s study was to elucidate the role of reductive carboxylation in redox metabolism, a process believed to be important for metastatic cancer. Reductive carboxylation is best known as a metabolic pathway that provides a molecule called acetyl-CoA so that it can be turned into lipids, which is mediated by fatty acid synthase (FASN). The FASN-mediated lipogenesis process supports rapid growth in most proliferating cancer cells, and increased FASN expression has been viewed as a metabolic feature of cancer cells. Thus, FASN is considered a potential target to block tumor growth.<\/p>\n<hr>\n<p>New research has identified that preventing the metabolic adaptations needed for cancer to metastasize could provide a target for treating patients with metastatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a recent study led by Lei Jiang, Ph.D., an assistant professor of molecular and cellular endocrinology, a team of researchers from City of Hope and the University of Texas Southwestern Medical Center, found a potential new target for treating patients with metastatic cancer. Their findings were published in the August 29 issue of the [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-173216","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/173216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=173216"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/173216\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=173216"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=173216"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=173216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}