{"id":173010,"date":"2023-09-28T21:26:13","date_gmt":"2023-09-29T02:26:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/09\/regulation-of-liver-subcellular-architecture-controls-metabolic-homeostasis"},"modified":"2023-09-28T21:26:13","modified_gmt":"2023-09-29T02:26:13","slug":"regulation-of-liver-subcellular-architecture-controls-metabolic-homeostasis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/09\/regulation-of-liver-subcellular-architecture-controls-metabolic-homeostasis","title":{"rendered":"Regulation of liver subcellular architecture controls metabolic homeostasis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/regulation-of-liver-subcellular-architecture-controls-metabolic-homeostasis.jpg\"><\/a><\/p>\n<p>Fascinating 3D electron microscopy study by Parlakg\u00fcl <i>et al.<\/i> wherein they compare the subcellular organization of liver tissue from lean and obese mice. The authors found substantial differences in endoplasmic reticulum (ER) organization. These ER differences were shown to directly influence metabolic health in a causal fashion, opening the doors to new ways of treating metabolic dysfunction. #electronmicroscopy #cellbiology #metabolism<\/p>\n<hr>\n<p>Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fascinating 3D electron microscopy study by Parlakg\u00fcl et al. wherein they compare the subcellular organization of liver tissue from lean and obese mice. The authors found substantial differences in endoplasmic reticulum (ER) organization. These ER differences were shown to directly influence metabolic health in a causal fashion, opening the doors to new ways of treating [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1495,6],"tags":[],"class_list":["post-173010","post","type-post","status-publish","format-standard","hentry","category-health","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/173010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=173010"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/173010\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=173010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=173010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=173010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}