{"id":172934,"date":"2023-09-27T23:24:53","date_gmt":"2023-09-28T04:24:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/09\/combination-radiation-with-immunotherapy-shows-promise-against-cold-breast-cancer-tumors"},"modified":"2023-09-27T23:24:53","modified_gmt":"2023-09-28T04:24:53","slug":"combination-radiation-with-immunotherapy-shows-promise-against-cold-breast-cancer-tumors","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/09\/combination-radiation-with-immunotherapy-shows-promise-against-cold-breast-cancer-tumors","title":{"rendered":"Combination radiation with immunotherapy shows promise against \u2018cold\u2019 breast cancer tumors"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/combination-radiation-with-immunotherapy-shows-promise-against-cold-breast-cancer-tumors2.jpg\"><\/a><\/p>\n<p>Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy\u2014one that boosts T cells, and another that boosts dendritic cells\u2014can control tumors in preclinical models of triple negative breast cancer, a cancer type that\u2019s typically resistant to immunotherapy alone. Immunotherapy activates the body\u2019s own immune system to fight cancer but isn\u2019t effective for difficult-to-treat \u201ccold\u201d tumors, like this.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-40844-3\">The findings<\/a> were published Aug. 24 in <i>Nature Communications<\/i>. Though <a href=\"https:\/\/medicalxpress.com\/tags\/radiation\/\" rel=\"tag\" class=\"\">radiation<\/a> therapy has previously been combined with T-cell boosting immunotherapy, it rarely succeeds in eliminating cold tumors. The new, <a href=\"https:\/\/medicalxpress.com\/tags\/preclinical+study\/\" rel=\"tag\" class=\"\">preclinical study<\/a> found that activating another type of immune cell called a dendritic cell, in addition to the other two approaches, produced a synergistic effect that elicited <a href=\"https:\/\/medicalxpress.com\/tags\/tumor\/\" rel=\"tag\" class=\"\">tumor<\/a> regression.<\/p>\n<p>\u201cI think this is quite exciting,\u201d said principal investigator Dr. Sandra Demaria, professor of radiation oncology at Weill Cornell Medicine and pathologist at NewYork-Presbyterian\/Weill Cornell Medical Center, who conducted the research under the auspices of the Department of Radiation Oncology. \u201cThere is so much room for improvement to provide more effective therapeutic options, especially for patients with cold tumors.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy\u2014one that boosts T cells, and another that boosts dendritic cells\u2014can control tumors in preclinical models of triple negative breast cancer, a cancer type that\u2019s typically resistant to immunotherapy alone. Immunotherapy activates the body\u2019s own immune system to fight cancer [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-172934","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/172934","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=172934"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/172934\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=172934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=172934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=172934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}