{"id":172631,"date":"2023-09-23T14:27:27","date_gmt":"2023-09-23T19:27:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/09\/split-gene-editing-tool-offers-greater-precision"},"modified":"2023-09-23T14:27:27","modified_gmt":"2023-09-23T19:27:27","slug":"split-gene-editing-tool-offers-greater-precision","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/09\/split-gene-editing-tool-offers-greater-precision","title":{"rendered":"Split gene-editing tool offers greater precision"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/split-gene-editing-tool-offers-greater-precision.jpg\"><\/a><\/p>\n<p>To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.<\/p>\n<p>Researchers in the lab of chemical and biomolecular engineer <a href=\"https:\/\/profiles.rice.edu\/faculty\/xue-sherry-gao\"> Xue Sherry Gao<\/a> created a <a href=\"https:\/\/en.wikipedia.org\/wiki\/CRISPR\">CRISPR<\/a>-based gene editor designed to target <a href=\"https:\/\/en.wikipedia.org\/wiki\/Adenine\"> adenine<\/a> \u23af one of the four main DNA <a href=\"https:\/\/en.wikipedia.org\/wiki\/Nucleotide\"> building blocks<\/a> \u23af that remains inactive when disassembled but kicks into gear once the binding molecule is added.<\/p>\n<p>Compared to the intact original, the split editor is more precise and stays active for a narrower window of time, which is important for avoiding off-target edits. Moreover, the activating small molecule used to bind the two pieces of the tool together is already being used as an anticancer and immunosuppressive drug.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added. Researchers in the lab of chemical and biomolecular engineer Xue Sherry Gao created a CRISPR-based gene editor designed to target adenine \u23af one of [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412],"tags":[],"class_list":["post-172631","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/172631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=172631"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/172631\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=172631"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=172631"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=172631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}