{"id":171607,"date":"2023-09-08T16:23:05","date_gmt":"2023-09-08T21:23:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/09\/exercise-induced-hormone-irisin-may-reduce-alzheimers-disease-plaque-and-tangle-pathology-in-the-brain"},"modified":"2023-09-08T16:23:05","modified_gmt":"2023-09-08T21:23:05","slug":"exercise-induced-hormone-irisin-may-reduce-alzheimers-disease-plaque-and-tangle-pathology-in-the-brain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/09\/exercise-induced-hormone-irisin-may-reduce-alzheimers-disease-plaque-and-tangle-pathology-in-the-brain","title":{"rendered":"Exercise-induced hormone irisin may reduce Alzheimer\u2019s disease plaque and tangle pathology in the brain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/exercise-induced-hormone-irisin-may-reduce-alzheimers-disease-plaque-and-tangle-pathology-in-the-brain.jpg\"><\/a><\/p>\n<p>Researchers who previously developed the first 3D human cell culture models of Alzheimer\u2019s disease (AD) that displays two major hallmarks of the condition\u2014the generation of amyloid beta deposits followed by tau tangles\u2014have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.<\/p>\n<p>As reported in the journal <i>Neuron<\/i>, the Massachusetts General Hospital (MGH)\u2013led team has uncovered promising results suggesting that irisin-based therapies might help combat AD.<\/p>\n<p>Physical exercise has been shown to reduce <a href=\"https:\/\/medicalxpress.com\/tags\/amyloid+beta\/\" rel=\"tag\" class=\"\">amyloid beta<\/a> deposits in various mouse models of AD, but the mechanisms involved have remained a mystery.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers who previously developed the first 3D human cell culture models of Alzheimer\u2019s disease (AD) that displays two major hallmarks of the condition\u2014the generation of amyloid beta deposits followed by tau tangles\u2014have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology. As reported in the journal Neuron, the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495,47],"tags":[],"class_list":["post-171607","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/171607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=171607"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/171607\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=171607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=171607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=171607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}