{"id":170875,"date":"2023-08-29T23:23:29","date_gmt":"2023-08-30T04:23:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/the-role-of-senescence-in-crafting-cancer-friendly-microenvironments"},"modified":"2023-08-29T23:23:29","modified_gmt":"2023-08-30T04:23:29","slug":"the-role-of-senescence-in-crafting-cancer-friendly-microenvironments","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/the-role-of-senescence-in-crafting-cancer-friendly-microenvironments","title":{"rendered":"The Role of Senescence in Crafting Cancer-Friendly Microenvironments"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-role-of-senescence-in-crafting-cancer-friendly-microenvironments.jpg\"><\/a><\/p>\n<p>The incidence of cancer increases exponentially as we age. Unlike most age-related diseases, which generally cause cell and tissue degeneration and loss of function, cancer cells must acquire different, albeit aberrant, functions to progress to lethal disease. One link between age-related cancer and degeneration could be an inflammatory tissue environment driven by MTOR in senescent cells.<\/p>\n<p>In her groundbreaking 2010 research perspective paper, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4166495\/\">The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression<\/a>, <a href=\"https:\/\/www.buckinstitute.org\/lab\/campisi-lab\/\">Dr. Judith Campisi<\/a> from the <a href=\"https:\/\/www.buckinstitute.org\/\">Buck Institute for Research on Aging<\/a> highlighted the tumor-promoting aspects of senescent cells. Campisi\u2019s research showcased the significant ability of senescent cells to reshape the cellular landscape around them, crafting what scientists term the \u2018microenvironment.\u2019<\/p>\n<p>Far from being an inert backdrop, this microenvironment serves as a dynamic stage upon which cells interact and potentially pave the way for disease progression, particularly cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The incidence of cancer increases exponentially as we age. Unlike most age-related diseases, which generally cause cell and tissue degeneration and loss of function, cancer cells must acquire different, albeit aberrant, functions to progress to lethal disease. One link between age-related cancer and degeneration could be an inflammatory tissue environment driven by MTOR in senescent [\u2026]<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-170875","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=170875"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170875\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=170875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=170875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=170875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}