{"id":170802,"date":"2023-08-28T23:23:07","date_gmt":"2023-08-29T04:23:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/naked-mole-rats-longevity-gene-extends-lifespan-and-health-of-mice"},"modified":"2023-08-28T23:23:07","modified_gmt":"2023-08-29T04:23:07","slug":"naked-mole-rats-longevity-gene-extends-lifespan-and-health-of-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/naked-mole-rats-longevity-gene-extends-lifespan-and-health-of-mice","title":{"rendered":"Naked mole-rat\u2019s \u2018longevity\u2019 gene extends lifespan and health of mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/naked-mole-rats-longevity-gene-extends-lifespan-and-health-of-mice2.jpg\"><\/a><\/p>\n<p>Scientists from the University of Rochester have had the naked mole-rat (<i>Heterocephalus glaber<\/i>) in their crosshairs for some time, previously identifying how their unique cellular aging mechanisms lay the foundation for their long lifespans \u2013 up to 41 years, during which the females also remain fertile \u2013 and resistance to age-related diseases.<\/p>\n<p>The modification directly led to the improved overall health of the aging mice and an approximate 4.4% increase in median lifespan.<\/p>\n<hr>\n<p>They weigh about an ounce, spend their lives underground in sub-Saharan Africa and are unlikely to be making the shortlist for any cute animal calendars, but the naked mole-rat continues to show scientists it has incredible age-resistant biology beneath its pale, wrinkly skin.<\/p>\n<p>Building on that knowledge, the researchers genetically modified mice to produce the naked mole-rat version of the hyaluronan synthase 2 gene, which makes a protein that produces high molecular weight hyaluronic acid (HMW-HA). While all mammals have hyaluronan synthase 2, the naked mole-rat\u2019s version is somehow enhanced, driving stronger gene expression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from the University of Rochester have had the naked mole-rat (Heterocephalus glaber) in their crosshairs for some time, previously identifying how their unique cellular aging mechanisms lay the foundation for their long lifespans \u2013 up to 41 years, during which the females also remain fertile \u2013 and resistance to age-related diseases. The modification directly [\u2026]<\/p>\n","protected":false},"author":542,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-170802","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/542"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=170802"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170802\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=170802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=170802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=170802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}