{"id":170727,"date":"2023-08-27T19:27:26","date_gmt":"2023-08-28T00:27:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/bioactive-near-infrared-ii-clusters-for-3d-imaging-and-acute-inflammation-inhibition"},"modified":"2023-08-27T19:27:26","modified_gmt":"2023-08-28T00:27:26","slug":"bioactive-near-infrared-ii-clusters-for-3d-imaging-and-acute-inflammation-inhibition","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/bioactive-near-infrared-ii-clusters-for-3d-imaging-and-acute-inflammation-inhibition","title":{"rendered":"Bioactive near-infrared II clusters for 3D imaging and acute inflammation inhibition"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/bioactive-near-infrared-ii-clusters-for-3d-imaging-and-acute-inflammation-inhibition2.jpg\"><\/a><\/p>\n<p>The bioactivity of most <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2021.750404\/full\">near-infrared II (NIRII) fluorophores<\/a> are limited, thereby conflicting the achievement of strong fluorescence and high catalytic activities, due to a lack of free electrons in the method.<\/p>\n<p>To overcome this challenge, Huizhen Ma and a research team in translational medicine, <a href=\"https:\/\/phys.org\/tags\/neural+engineering\/\" rel=\"tag\" class=\"\">neural engineering<\/a>, physics, and materials at the Tianjin University China developed atomically precise gold clusters with strong near-infrared II fluorescence to show potent enzyme-mimetic activities by using atomic engineering, to form active copper single-atom sites.<\/p>\n<p>These gold-copper clusters (Au<sub>21 <\/sub>Cu<sub>1<\/sub>) showed higher antioxidant nature with a 90-fold catalase-like and 3-fold higher superoxide dismutase-like activity compared to gold clusters alone. These clusters can be cleared through the <a href=\"https:\/\/phys.org\/tags\/kidney\/\" rel=\"tag\" class=\"\">kidney<\/a> to monitor cisplatin-induced <a href=\"https:\/\/phys.org\/tags\/renal+injury\/\" rel=\"tag\" class=\"\">renal injury<\/a> within a 20\u2013120-minute window to visualize the process in 3D via <a href=\"https:\/\/www.nature.com\/articles\/s41592-019-0398-7\">near-infrared light-sheet microscopy<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The bioactivity of most near-infrared II (NIRII) fluorophores are limited, thereby conflicting the achievement of strong fluorescence and high catalytic activities, due to a lack of free electrons in the method. To overcome this challenge, Huizhen Ma and a research team in translational medicine, neural engineering, physics, and materials at the Tianjin University China developed [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,47],"tags":[],"class_list":["post-170727","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=170727"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170727\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=170727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=170727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=170727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}