{"id":170226,"date":"2023-08-22T17:24:42","date_gmt":"2023-08-22T22:24:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/ai-can-now-design-proteins-that-behave-like-biological-transistors"},"modified":"2023-08-22T17:24:42","modified_gmt":"2023-08-22T22:24:42","slug":"ai-can-now-design-proteins-that-behave-like-biological-transistors","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/ai-can-now-design-proteins-that-behave-like-biological-transistors","title":{"rendered":"AI Can Now Design Proteins That Behave Like Biological \u2018Transistors\u2019"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ai-can-now-design-proteins-that-behave-like-biological-transistors3.jpg\"><\/a><\/p>\n<p>Enter AI. Multiple deep learning methods can already accurately predict protein structures\u2014 <a href=\"https:\/\/singularityhub.com\/2021\/07\/20\/new-protein-folding-ai-just-made-a-once-in-a-generation-advance-in-biology\/\">a breakthrough half a century in the making<\/a>. Subsequent studies using increasingly powerful algorithms have hallucinated protein structures untethered by the forces of evolution.<\/p>\n<p>Yet these AI-generated structures have a downfall: although highly intricate, most are completely static\u2014essentially, a sort of digital protein sculpture frozen in time.<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adg7731\">A new study<\/a> in <em>Science<\/em> this month broke the mold by adding flexibility to designer proteins. The new structures aren\u2019t contortionists without limits. However, the designer proteins can stabilize into two different forms\u2014think a hinge in either an open or closed configuration\u2014depending on an external biological \u201clock.\u201d Each state is analogous to a computer\u2019s \u201c0\u201d or \u201c1,\u201d which subsequently controls the cell\u2019s output.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Enter AI. Multiple deep learning methods can already accurately predict protein structures\u2014 a breakthrough half a century in the making. Subsequent studies using increasingly powerful algorithms have hallucinated protein structures untethered by the forces of evolution. Yet these AI-generated structures have a downfall: although highly intricate, most are completely static\u2014essentially, a sort of digital protein [\u2026]<\/p>\n","protected":false},"author":599,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,41,6],"tags":[],"class_list":["post-170226","post","type-post","status-publish","format-standard","hentry","category-biological","category-information-science","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/599"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=170226"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/170226\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=170226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=170226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=170226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}