{"id":169973,"date":"2023-08-18T15:28:18","date_gmt":"2023-08-18T20:28:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/new-research-has-major-implications-for-controlling-t-cell-activity"},"modified":"2023-08-18T15:28:18","modified_gmt":"2023-08-18T20:28:18","slug":"new-research-has-major-implications-for-controlling-t-cell-activity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/new-research-has-major-implications-for-controlling-t-cell-activity","title":{"rendered":"New research has major implications for controlling T cell activity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-research-has-major-implications-for-controlling-t-cell-activity2.jpg\"><\/a><\/p>\n<p>According to new research in the journal <i>Immunity<\/i>, T cells have a nuclear receptor doing something very odd\u2014but very important\u2014to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid receptor alpha (RAR\u03b1), is known to control gene expression programs in the nucleus, but it also now appears to operate outside the cell nucleus to coordinate the early events triggered at the cell surface that lead to T cell activation.<\/p>\n<p>Scientists wouldn\u2019t normally expect to see a nuclear receptor such as RAR\u03b1 playing this role outside the cell nucleus. And yet the new findings suggest T cells cannot begin to fight disease without a form of RAR\u03b1 on the scene in the cytoplasm.<\/p>\n<p>\u201cCytoplasmic retinoic acid receptors turn out to be central for a T cell to link sensing at the <a href=\"https:\/\/medicalxpress.com\/tags\/cell+surface\/\" rel=\"tag\" class=\"\">cell surface<\/a> with downstream signaling cascades and gene expression programs that transform the T cell to become an active fighter,\u201d says Professor Hilde Cheroutre, Ph.D., who led the new study at La Jolla Institute for Immunology (LJI) with LJI Assistant Professor Samuel Myers, Ph.D., LJI Professor Mitchell Kronenberg, Ph.D., and LJI Professor Emeritus Amnon Altman, Ph.D.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd\u2014but very important\u2014to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid receptor alpha (RAR\u03b1), is known to control gene expression programs in the nucleus, but it also now appears to operate outside the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-169973","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169973"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169973\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}