{"id":169968,"date":"2023-08-18T15:27:21","date_gmt":"2023-08-18T20:27:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/following-chronic-fatigue-mechanisms-to-the-source-wasf3-and-mitochondrial-respiration"},"modified":"2023-08-18T15:27:21","modified_gmt":"2023-08-18T20:27:21","slug":"following-chronic-fatigue-mechanisms-to-the-source-wasf3-and-mitochondrial-respiration","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/following-chronic-fatigue-mechanisms-to-the-source-wasf3-and-mitochondrial-respiration","title":{"rendered":"Following chronic fatigue mechanisms to the source: WASF3 and mitochondrial respiration"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/following-chronic-fatigue-mechanisms-to-the-source-wasf3-and-mitochondrial-respiration2.jpg\"><\/a><\/p>\n<p>Researchers at the National Heart, Lung, and Blood Institute at NIH, Bethesda, have discovered a potential breakthrough for people with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), marked by extreme exhaustion, post-exertional malaise and cognitive issues.<\/p>\n<p>In a paper, \u201cWASF3 disrupts <a href=\"https:\/\/medicalxpress.com\/tags\/mitochondrial+respiration\/\" rel=\"tag\" class=\"\">mitochondrial respiration<\/a> and may mediate exercise intolerance in <a href=\"https:\/\/medicalxpress.com\/tags\/myalgic+encephalomyelitis\/\" rel=\"tag\" class=\"\">myalgic encephalomyelitis<\/a>\/<a href=\"https:\/\/medicalxpress.com\/tags\/chronic+fatigue+syndrome\/\" rel=\"tag\" class=\"\">chronic fatigue syndrome<\/a>,\u201d published in <i>PNAS<\/i>, the team details the influence of increased WASF3 proteins on the assembly of mitochondrial proteins, hampering energy production.<\/p>\n<p>The study focused on a woman (S1) who experienced severe long-term fatigue. Measuring her muscles for phosphocreatine regeneration after exercise revealed a significant delay in mitochondrial ATP synthesis capacity. This discovery was followed up with a cell assay which found increased phospho-activation of an enzyme in a signaling pathway (MPAK).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the National Heart, Lung, and Blood Institute at NIH, Bethesda, have discovered a potential breakthrough for people with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), marked by extreme exhaustion, post-exertional malaise and cognitive issues. In a paper, \u201cWASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis\/chronic fatigue syndrome,\u201d published in PNAS, the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495,47],"tags":[],"class_list":["post-169968","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169968"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169968\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}