{"id":169967,"date":"2023-08-18T15:27:04","date_gmt":"2023-08-18T20:27:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/machine-learning-advances-personalized-cancer-vaccines-via-bigmhc"},"modified":"2023-08-18T15:27:04","modified_gmt":"2023-08-18T20:27:04","slug":"machine-learning-advances-personalized-cancer-vaccines-via-bigmhc","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/machine-learning-advances-personalized-cancer-vaccines-via-bigmhc","title":{"rendered":"Machine Learning Advances Personalized Cancer Vaccines via BigMHC"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/machine-learning-advances-personalized-cancer-vaccines-via-bigmhc.jpg\"><\/a><\/p>\n<p>A <a href=\"https:\/\/www.nature.com\/articles\/s42256-023-00694-6\">recent study<\/a> published in <em>Nature Machine Intelligence<\/em> examines a novel deep-learning method known as BigMHC, which can predict when the immune system will respond to triggers from cancer-related protein fragments, thus killing the tumors. This study was led and conducted by a team of researchers at Johns Hopkins University and holds the potential to develop personalized cancer immunotherapies and vaccines.<\/p>\n<p><em>Rendition of cytotoxic CD8+ T-cells identifying cancer cells via receptor binding neoantigens. (Credit: Image generated by DALL-E 2 from OpenAI)<\/em><\/p>\n<p>\u201cCancer immunotherapy is designed to activate a patient\u2019s immune system to destroy cancer cells,\u201d <a href=\"https:\/\/www.eurekalert.org\/news-releases\/998118\">said Dr. Rachel Karchin<\/a>, who is a professor of biomedical engineering, oncology and computer science at Johns Hopkins University, and a co-author on the study. \u201cA critical step in the process is immune system recognition of cancer cells through T-cell binding to cancer-specific protein fragments on the cell surface.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study published in Nature Machine Intelligence examines a novel deep-learning method known as BigMHC, which can predict when the immune system will respond to triggers from cancer-related protein fragments, thus killing the tumors. This study was led and conducted by a team of researchers at Johns Hopkins University and holds the potential to [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-169967","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169967"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169967\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}