{"id":169829,"date":"2023-08-17T01:23:05","date_gmt":"2023-08-17T06:23:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/researchers-achieve-high-speed-super-resolution-imaging-with-a-large-field-of-view"},"modified":"2023-08-17T01:23:05","modified_gmt":"2023-08-17T06:23:05","slug":"researchers-achieve-high-speed-super-resolution-imaging-with-a-large-field-of-view","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/researchers-achieve-high-speed-super-resolution-imaging-with-a-large-field-of-view","title":{"rendered":"Researchers achieve high-speed super-resolution imaging with a large field of view"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-achieve-high-speed-super-resolution-imaging-with-a-large-field-of-view.jpg\"><\/a><\/p>\n<p>Researchers have developed a fluorescence microscope that uses structured illumination for fast super-resolution imaging over a wide field of view. The new microscope was designed to image multiple living cells simultaneously with a very high resolution to study the effects of various drugs and mixtures of drugs on the body.<\/p>\n<p>\u201cPolypharmacy\u2014the effect of the many combinations of drugs typically prescribed to the chronically sick or elderly\u2014can lead to dangerous interactions and is becoming a major issue,\u201d said Henning Ortkrass from Bielefeld University in Germany. \u201cWe developed this microscope as part of the EIC Pathfinder OpenProject DeLIVERy, which aims to develop a platform that can investigate polypharmacy in individual patients.\u201d<\/p>\n<p>In the journal <i>Optics Express<\/i>, the researchers describe their new microscope, which uses optical fiber delivery of excitation light to enable very high image quality over a very large field of view with multicolor and high-speed capability. They show that the instrument can be used to image <a href=\"https:\/\/phys.org\/tags\/liver+cells\/\" rel=\"tag\" class=\"\">liver cells<\/a>, achieving a field of view up to 150 \u00d7 150 \u03bcm<sup>2<\/sup> and imaging rates up to 44 Hz while maintaining a spatiotemporal resolution of less than 100 nm.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have developed a fluorescence microscope that uses structured illumination for fast super-resolution imaging over a wide field of view. The new microscope was designed to image multiple living cells simultaneously with a very high resolution to study the effects of various drugs and mixtures of drugs on the body. \u201cPolypharmacy\u2014the effect of the many [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-169829","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169829"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169829\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}