{"id":169704,"date":"2023-08-15T03:22:43","date_gmt":"2023-08-15T08:22:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/a-new-kind-of-brain-organoid-offers-possibilities-in-neuroscience-research"},"modified":"2023-08-15T03:22:43","modified_gmt":"2023-08-15T08:22:43","slug":"a-new-kind-of-brain-organoid-offers-possibilities-in-neuroscience-research","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/a-new-kind-of-brain-organoid-offers-possibilities-in-neuroscience-research","title":{"rendered":"A new kind of brain organoid offers possibilities in neuroscience research"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-new-kind-of-brain-organoid-offers-possibilities-in-neuroscience-research2.jpg\"><\/a><\/p>\n<p>University of Michigan researchers published a<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.51820\"> study<\/a> detailing a new method for making brain organoids, or miniature lab-grown brains used in neuroscience research, last June. Previously, the most common method for creating human brain organoids relied on<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9733768\/\"> Matrigel<\/a> \u2014 a substance made of cells from mouse sarcomas \u2014 to provide structure for the organoids, but the new method uses an engineered extracellular matrix composed of human-derived proteins.<\/p>\n<p>The lack of cells from other species in the new organoids means they more closely resemble actual human brains, opening up research possibilities on neurodegenerative diseases such as Alzheimer\u2019s and Parkinson\u2019s. U-M alum Ayse Mu\u00f1iz, who worked on the research as part of her Ph.D. thesis while at the University, said in an interview with The Michigan Daily that having organoids with only human cells is advantageous for translational research \u2014 the process of turning knowledge from lab research into something with real-world applications.<\/p>\n<p>\u201cWhen you\u2019re doing translational research, having contamination from other species will limit your ability to translate this into the clinic,\u201d Mu\u00f1iz said. \u201cThe presence of other species basically elicits immunogenic responses, and can just be a limitation for scale and other things like that. And so here now that you\u2019ve taken that out, it makes the path to translation a lot easier.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Michigan researchers published a study detailing a new method for making brain organoids, or miniature lab-grown brains used in neuroscience research, last June. Previously, the most common method for creating human brain organoids relied on Matrigel \u2014 a substance made of cells from mouse sarcomas \u2014 to provide structure for the organoids, but [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-169704","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169704"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169704\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}