{"id":169407,"date":"2023-08-10T08:26:20","date_gmt":"2023-08-10T13:26:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/isothermal-self-assembly-of-multicomponent-and-evolutive-dna-nanostructures"},"modified":"2023-08-10T08:26:20","modified_gmt":"2023-08-10T13:26:20","slug":"isothermal-self-assembly-of-multicomponent-and-evolutive-dna-nanostructures","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/isothermal-self-assembly-of-multicomponent-and-evolutive-dna-nanostructures","title":{"rendered":"Isothermal self-assembly of multicomponent and evolutive DNA nanostructures"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/isothermal-self-assembly-of-multicomponent-and-evolutive-dna-nanostructures3.jpg\"><\/a><\/p>\n<p>Multiple complementary DNA strands can be thermally annealed into desired entities to engineer DNA nanostructures. In a new study now published in <i><i>Nature<\/i> Nanotechnology<\/i>, Caroline Rossi-Gendron and a team of researchers in chemistry, materials science and biology in France and Japan used a magnesium-free buffer containing sodium chloride, complex cocktails of DNA strands and proteins to self-assemble isothermally at room temperature or physiological temperature into user-defined nanostructures including <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16464044\/\">nanogrids<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2451929417300785#:~:text=DNA%20origami%20is%20a%20process, to%20different%20parts%20of%20the\">DNA origami<\/a> and single-stranded tile assemblies.<\/p>\n<p>This <a href=\"https:\/\/phys.org\/tags\/self-assembly\/\" rel=\"tag\" class=\"\">self-assembly<\/a> relied on thermodynamics, proceeding through multiple folding pathways to create highly configurable nanostructures. The method allowed the self-selection of the most stable shape in a large pool of competitive DNA strands. Interestingly, DNA <a href=\"https:\/\/phys.org\/tags\/origami\/\" rel=\"tag\" class=\"\">origami<\/a> can shift isothermally from an initially stable shape to a radically different one through an exchange of constitutive staple strands. This expanded the collection of shapes and functions obtained via isothermal self-assembly to create the foundation for adaptive nanomachines and facilitate evolutionary nanostructure discovery.<\/p>\n<p>Self-assembly occurs when naturally occurring or rationally designed entities can embed necessary information to spontaneously interact and self-organize into <a href=\"https:\/\/doi.org\/10.1126%2Fscience.1070821\">functional superstructures<\/a> of interest. Typically, synthetic self-assembled materials result from the organization of a repeating single component to create a stable supramolecular assembly containing micelles or colloidal crystals with a prescribed set of useful properties. Such constructs have limited reconfigurability, making it highly challenging to produce the desired structures.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Multiple complementary DNA strands can be thermally annealed into desired entities to engineer DNA nanostructures. In a new study now published in Nature Nanotechnology, Caroline Rossi-Gendron and a team of researchers in chemistry, materials science and biology in France and Japan used a magnesium-free buffer containing sodium chloride, complex cocktails of DNA strands and proteins [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,4],"tags":[],"class_list":["post-169407","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169407"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169407\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}