{"id":169065,"date":"2023-08-05T04:25:16","date_gmt":"2023-08-05T09:25:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/new-simple-and-accessible-method-creates-potency-increasing-structure-in-drugs"},"modified":"2023-08-05T04:25:16","modified_gmt":"2023-08-05T09:25:16","slug":"new-simple-and-accessible-method-creates-potency-increasing-structure-in-drugs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/new-simple-and-accessible-method-creates-potency-increasing-structure-in-drugs","title":{"rendered":"New, simple and accessible method creates potency-increasing structure in drugs"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-simple-and-accessible-method-creates-potency-increasing-structure-in-drugs3.jpg\"><\/a><\/p>\n<p>Chemical structures called cyclopropanes can increase the potency and fine-tune the properties of many drugs, but traditional methods to create this structure only work with certain molecules and require highly reactive\u2014potentially explosive\u2014ingredients.<\/p>\n<p>Now, a team of researchers from Penn State has identified and demonstrated a safe, efficient and practical way to create cyclopropanes on a wide variety of molecules using a previously undescribed chemical process. With additional development, the new method\u2014described in a paper publishing Aug. 4 in the journal <i>Science <\/i>\u2014could transform how this important process occurs during <a href=\"https:\/\/phys.org\/tags\/drug+development\/\" rel=\"tag\" class=\"\">drug development<\/a> and creation.<\/p>\n<p>Cyclopropanes are a key feature in many drugs currently approved by the U.S. Food and Drug Administration, including those used to treat COVID-19, asthma, hepatitis C, and HIV\/AIDs. These structures can increase a drug\u2019s potency, alter its ability to dissolve in the body, minimize its interactions with unintended targets, and otherwise fine-tune performance. Cyclopropanes are a ring of three connected carbon atoms, with one carbon attached to the rest of the drug molecule and the other two each attached to two hydrogen atoms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chemical structures called cyclopropanes can increase the potency and fine-tune the properties of many drugs, but traditional methods to create this structure only work with certain molecules and require highly reactive\u2014potentially explosive\u2014ingredients. Now, a team of researchers from Penn State has identified and demonstrated a safe, efficient and practical way to create cyclopropanes on a [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-169065","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=169065"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/169065\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=169065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=169065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=169065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}