{"id":168977,"date":"2023-08-03T16:22:52","date_gmt":"2023-08-03T21:22:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/08\/a-protein-essential-to-the-fight-against-bacterial-invaders-is-revealed"},"modified":"2023-08-03T16:22:52","modified_gmt":"2023-08-03T21:22:52","slug":"a-protein-essential-to-the-fight-against-bacterial-invaders-is-revealed","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/08\/a-protein-essential-to-the-fight-against-bacterial-invaders-is-revealed","title":{"rendered":"A Protein Essential to the Fight Against Bacterial Invaders is Revealed"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/2812ion3aUk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Scientists have shown that a protein called NLRP11 has an essential role in the immune system; it alerts the body that a bacterial infection is occurring, triggering an immune response that battles the bacterial invader. NLRP11 appears to identify bacteria that are taken up by immune cells called macrophages, by recognizing a part of the bacterial coat. These findings have provided new insights into our understanding of the immune response to bacterial infection, and have been <a href=\"https:\/\/dx.doi.org\/10.1126\/sciimmunol.abo4767\">reported in <em>Science Immunology<\/em><\/a>.<\/p>\n<p>The NLRP11 protein is expressed by humans, but not mice, which are a common animal model for infection. In this study, the researchers overcame that gap by using a mouse model that expressed a so-called humanized immune system. <a href=\"http:\/\/pubmed.ncbi.nlm.nih.gov\/28543438\/\">Humanized mice<\/a> have been grafted with human cells and tissues so they replicate human biological functions more accurately.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have shown that a protein called NLRP11 has an essential role in the immune system; it alerts the body that a bacterial infection is occurring, triggering an immune response that battles the bacterial invader. NLRP11 appears to identify bacteria that are taken up by immune cells called macrophages, by recognizing a part of the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-168977","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=168977"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168977\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=168977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=168977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=168977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}