{"id":168691,"date":"2023-07-30T16:22:58","date_gmt":"2023-07-30T21:22:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/07\/genome-editing-prevents-hypertrophic-cardiomyopathy-in-mice"},"modified":"2023-07-30T16:22:58","modified_gmt":"2023-07-30T21:22:58","slug":"genome-editing-prevents-hypertrophic-cardiomyopathy-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/07\/genome-editing-prevents-hypertrophic-cardiomyopathy-in-mice","title":{"rendered":"Genome editing prevents hypertrophic cardiomyopathy in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/genome-editing-prevents-hypertrophic-cardiomyopathy-in-mice2.jpg\"><\/a><\/p>\n<p>In a recent study published in the journal <a href=\"https:\/\/www.nature.com\/articles\/s41591-022-02190-7\" rel=\"noopener\"><em>Nature Medicine<\/em><\/a>, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:<\/p>\n<p>I) an adenine base editor (ABE8e) <\/p>\n<p>Ii) a potent Cas9 nuclease delivered by an adeno-associated virus (AAV) vector.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a recent study published in the journal Nature Medicine, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows: I) an adenine base editor (ABE8e) Ii) a potent Cas9 nuclease delivered by an adeno-associated virus (AAV) [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-168691","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=168691"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168691\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=168691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=168691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=168691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}