{"id":168424,"date":"2023-07-27T02:23:13","date_gmt":"2023-07-27T07:23:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/07\/brain-single-cell-study-reveals-genes-that-may-be-involved-in-post-traumatic-stress-and-major-depressive-disorders"},"modified":"2023-07-27T02:23:13","modified_gmt":"2023-07-27T07:23:13","slug":"brain-single-cell-study-reveals-genes-that-may-be-involved-in-post-traumatic-stress-and-major-depressive-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/07\/brain-single-cell-study-reveals-genes-that-may-be-involved-in-post-traumatic-stress-and-major-depressive-disorders","title":{"rendered":"Brain single-cell study reveals genes that may be involved in post-traumatic stress and major depressive disorders"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-single-cell-study-reveals-genes-that-may-be-involved-in-post-traumatic-stress-and-major-depressive-disorders3.jpg\"><\/a><\/p>\n<p>An international team led by investigators at McLean Hospital has analyzed the genes expressed in approximately 575,000 individual cells from the brains of people with and without post-traumatic stress and major depressive disorders (PTSD and MDD), revealing new insights into the mechanisms behind the brain\u2019s stress response in these conditions.<\/p>\n<p>The findings, which are published in <i>The <i>American Journal of Psychiatry<\/i>,<\/i> could lead to novel markers of PTSD and MDD and well as new therapeutic targets.<\/p>\n<p>Because studies have implicated the <a href=\"https:\/\/medicalxpress.com\/tags\/dorsolateral+prefrontal+cortex\/\" rel=\"tag\" class=\"\">dorsolateral prefrontal cortex<\/a> (DLPFC) region of the brain in PTSD and MDD, the scientists compared the <a href=\"https:\/\/medicalxpress.com\/tags\/genes\/\" rel=\"tag\" class=\"\">genes<\/a> expressed in cells in DLPFC samples collected postmortem from 11 individuals with PTSD, 10 with MDD, and 11 without either of these conditions with a replication dataset half the size. The researchers detected which genes were expressed by which cells\u2014including eight different types of cells\u2014through a technique called single-cell RNA sequencing.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international team led by investigators at McLean Hospital has analyzed the genes expressed in approximately 575,000 individual cells from the brains of people with and without post-traumatic stress and major depressive disorders (PTSD and MDD), revealing new insights into the mechanisms behind the brain\u2019s stress response in these conditions. The findings, which are published [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-168424","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=168424"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168424\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=168424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=168424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=168424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}