{"id":168209,"date":"2023-07-24T04:24:14","date_gmt":"2023-07-24T09:24:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/07\/a-synthetic-biology-platform-enabling-control-over-aging-associated-stress-response"},"modified":"2023-07-24T04:24:14","modified_gmt":"2023-07-24T09:24:14","slug":"a-synthetic-biology-platform-enabling-control-over-aging-associated-stress-response","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/07\/a-synthetic-biology-platform-enabling-control-over-aging-associated-stress-response","title":{"rendered":"A synthetic biology platform enabling control over aging-associated stress response"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-synthetic-biology-platform-enabling-control-over-aging-associated-stress-response2.jpg\"><\/a><\/p>\n<p>Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety of pathological and aging-associated conditions.<\/p>\n<p>A new publication, \u201cOptogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape,\u201d authored by company founders and featured on the cover of <i>Cell Systems<\/i> describes a technique that triggers the ISR virtually using light and demonstrates how the accumulation of stress over time shifts a cell\u2019s reaction from adaptation to apoptosis (programmed cell death).<\/p>\n<p>\u201cIn a very real way, our platform puts cells into a virtual reality, making them experience stress in the absence of physical stressors,\u201d said Maxwell Wilson, Ph.D., a co-founder of Integrated Biosciences and Assistant Professor of Molecular, Cellular, and Developmental Biology at the University of California Santa Barbara.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,269,6,1879],"tags":[],"class_list":["post-168209","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-life-extension","category-robotics-ai","category-virtual-reality"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=168209"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/168209\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=168209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=168209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=168209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}