{"id":167278,"date":"2023-07-10T18:29:28","date_gmt":"2023-07-10T23:29:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/07\/existing-cancer-drug-ponatinib-could-be-repurposed-to-fight-certain-aggressive-cancers"},"modified":"2023-07-10T18:29:28","modified_gmt":"2023-07-10T23:29:28","slug":"existing-cancer-drug-ponatinib-could-be-repurposed-to-fight-certain-aggressive-cancers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/07\/existing-cancer-drug-ponatinib-could-be-repurposed-to-fight-certain-aggressive-cancers","title":{"rendered":"Existing cancer drug ponatinib could be repurposed to fight certain aggressive cancers"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/existing-cancer-drug-ponatinib-could-be-repurposed-to-fight-certain-aggressive-cancers.jpg\"><\/a><\/p>\n<p>A team of scientists led by Nanyang Technological University, Singapore (NTU Singapore) has found that an existing cancer drug could be repurposed to target a subset of cancers that currently lack targeted treatment options and are often associated with poor outcomes.<\/p>\n<p>This subset of cancers makes up 15% of all cancers and is especially prevalent in aggressive tumors such as osteosarcoma (bone tumor) and glioblastoma (brain tumor).<\/p>\n<p>These cancerous cells stay \u201cimmortal\u201d using a mechanism called the alternative lengthening of telomeres (ALT), but the team has demonstrated that ponatinib, a cancer <a href=\"https:\/\/medicalxpress.com\/tags\/drug\/\" rel=\"tag\" class=\"\">drug<\/a> approved by the US Food and Drug Administration, blocks key steps in the ALT mechanism that leads it to fail.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists led by Nanyang Technological University, Singapore (NTU Singapore) has found that an existing cancer drug could be repurposed to target a subset of cancers that currently lack targeted treatment options and are often associated with poor outcomes. This subset of cancers makes up 15% of all cancers and is especially prevalent [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-167278","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/167278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=167278"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/167278\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=167278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=167278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=167278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}