{"id":167219,"date":"2023-07-09T22:25:06","date_gmt":"2023-07-10T03:25:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/07\/how-b-cells-and-androgens-contribute-to-the-development-of-pcos"},"modified":"2023-07-09T22:25:06","modified_gmt":"2023-07-10T03:25:06","slug":"how-b-cells-and-androgens-contribute-to-the-development-of-pcos","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/07\/how-b-cells-and-androgens-contribute-to-the-development-of-pcos","title":{"rendered":"How B-cells and androgens contribute to the development of PCOS"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-b-cells-and-androgens-contribute-to-the-development-of-pcos2.jpg\"><\/a><\/p>\n<p>Research on mu heavy chain knockout mice (MuMt<sup>-<\/sup>; B<sup>null<\/sup>), which are mice that are genetically incapable of producing mature B-cells, has suggested that B-cells amplify the metabolic effects of diseases, especially diabetes and insulin resistance. Since type 2 diabetes (T2D) and hyperthyroidism, both of which are autoimmune conditions, are strongly correlated with PCOS, scientists have attempted to investigate an autoimmune trigger for PCOS, which has remained unsuccessful.<\/p>\n<p><b>Study findings<\/b><\/p>\n<p>In the present study, researchers evaluate previously hypothesized factors associated with cyst formation and inflammation, which include B-cell frequency, hyperandrogenemia, and <a href=\"https:\/\/www.news-medical.net\/health\/What-are-Autoantibodies.aspx\" class=\"\">autoantibodies<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research on mu heavy chain knockout mice (MuMt-; Bnull), which are mice that are genetically incapable of producing mature B-cells, has suggested that B-cells amplify the metabolic effects of diseases, especially diabetes and insulin resistance. Since type 2 diabetes (T2D) and hyperthyroidism, both of which are autoimmune conditions, are strongly correlated with PCOS, scientists have [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-167219","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/167219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=167219"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/167219\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=167219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=167219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=167219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}