{"id":16695,"date":"2015-08-26T14:47:21","date_gmt":"2015-08-26T21:47:21","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2015\/08\/can-we-reprogram-cancer-cells-back-to-normal"},"modified":"2017-06-04T11:45:28","modified_gmt":"2017-06-04T18:45:28","slug":"can-we-reprogram-cancer-cells-back-to-normal","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2015\/08\/can-we-reprogram-cancer-cells-back-to-normal","title":{"rendered":"Can We Reprogram Cancer Cells Back To Normal?"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/yGYTLOGZ40U?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Most cancer-busting strategies focus on removing cancerous cells. While this approach has proved extremely effective on many patients, most treatments have unpleasant side effects and there are many strains which prove extremely challenging to remove. An alternative model to this is to alter instead of remove \u2014 fixing cancerous behaviour by \u2018reprogramming\u2019 cells that go rogue; essentially swiss finishing school for cellular miscreants. A study published in Nature Cell Biology now provides hope that this tactic could in fact work in many cancers.<\/p>\n<p>Researchers from Mayo Clinic\u2019s Florida campus have found that adhesion proteins, which act like a glue sticking cells together, actually interact with a cell\u2019s \u2018microprocessor\u2019. This processor creates molecules called miRNAs, which regulate multiple genes and essentially activate or de-activate different behavioural programs (like commands in computer programming). When healthy cells bump into a neighbour and begin to glue together, these adhesion proteins normally influence both cells \u2014 tuning down growth pathways. In cancer, the lab found this adhesion is perturbed; de-regulating miRNA production and enabling rampant growth. When scientists corrected these miRNA levels, the growth was arrested.<\/p>\n<p>\u201cThe study brings together two so-far unrelated research fields \u2014 cell-to-cell adhesion and miRNA biology \u2014 to resolve a long-standing problem about the role of adhesion proteins in cell behavior that was baffling scientists. Most significantly, it uncovers a new strategy for cancer therapy\u201d<\/p>\n<p><a href=\"http:\/\/www.longevityreporter.org\/blog\/2015\/8\/25\/can-we-reprogram-cancer-cells-back-to-normal\" target=\"_blank\">Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Most cancer-busting strategies focus on removing cancerous cells. While this approach has proved extremely effective on many patients, most treatments have unpleasant side effects and there are many strains which prove extremely challenging to remove. An alternative model to this is to alter instead of remove \u2014 fixing cancerous behaviour by \u2018reprogramming\u2019 cells that go [\u2026]<\/p>\n","protected":false},"author":259,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,1495],"tags":[],"class_list":["post-16695","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/16695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/259"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=16695"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/16695\/revisions"}],"predecessor-version":[{"id":64367,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/16695\/revisions\/64367"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=16695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=16695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=16695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}