{"id":166599,"date":"2023-06-28T17:23:47","date_gmt":"2023-06-28T22:23:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/06\/researchers-uncover-new-crispr-like-system-in-animals-that-can-edit-the-human-genome"},"modified":"2023-06-28T17:23:47","modified_gmt":"2023-06-28T22:23:47","slug":"researchers-uncover-new-crispr-like-system-in-animals-that-can-edit-the-human-genome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/06\/researchers-uncover-new-crispr-like-system-in-animals-that-can-edit-the-human-genome","title":{"rendered":"Researchers uncover new CRISPR-like system in animals that can edit the human genome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-uncover-new-crispr-like-system-in-animals-that-can-edit-the-human-genome3.jpg\"><\/a><\/p>\n<p>A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes\u2014organisms that include fungi, plants, and animals.<\/p>\n<p>In a study published in <i>Nature<\/i>, the team describes how the system is based on a <a href=\"https:\/\/phys.org\/tags\/protein\/\" rel=\"tag\" class=\"\">protein<\/a> called Fanzor. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the <a href=\"https:\/\/phys.org\/tags\/genome\/\" rel=\"tag\" class=\"\">genome<\/a> of human cells. The compact Fanzor systems have the potential to be more easily delivered to cells and tissues as therapeutics than CRISPR\/Cas systems, and further refinements to improve their targeting efficiency could make them a valuable new technology for <a href=\"https:\/\/phys.org\/tags\/human+genome\/\" rel=\"tag\" class=\"\">human genome<\/a> editing.<\/p>\n<p>CRISPR\/Cas was first discovered in prokaryotes (bacteria and other single-cell organisms that lack nuclei) and scientists including Zhang\u2019s lab have long wondered whether similar systems exist in eukaryotes. The new study demonstrates that RNA-guided DNA-cutting mechanisms are present across all kingdoms of life.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes\u2014organisms that include fungi, plants, and animals. In a study published in Nature, the team describes how the system is based on [\u2026]<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-166599","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=166599"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166599\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=166599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=166599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=166599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}