{"id":166482,"date":"2023-06-27T02:23:45","date_gmt":"2023-06-27T07:23:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/06\/researchers-reveal-mechanism-of-protection-against-breast-and-ovarian-cancer"},"modified":"2023-06-27T02:23:45","modified_gmt":"2023-06-27T07:23:45","slug":"researchers-reveal-mechanism-of-protection-against-breast-and-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/06\/researchers-reveal-mechanism-of-protection-against-breast-and-ovarian-cancer","title":{"rendered":"Researchers reveal mechanism of protection against breast and ovarian cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-reveal-mechanism-of-protection-against-breast-and-ovarian-cancer2.jpg\"><\/a><\/p>\n<p>In a new paper published today in <i>Nature<\/i>, researchers at the Francis Crick Institute have outlined the structure and function of a protein complex that is required to repair damaged DNA and protect against cancer.<\/p>\n<p>Every time a cell replicates, mistakes can happen in the form of <a href=\"https:\/\/medicalxpress.com\/tags\/mutations\/\" rel=\"tag\" class=\"\">mutations<\/a>, but specialized proteins exist to repair the damaged DNA.<\/p>\n<p>People with mutations in a DNA repair <a href=\"https:\/\/medicalxpress.com\/tags\/protein\/\" rel=\"tag\" class=\"\">protein<\/a> called BRCA2 are predisposed to breast, ovarian and <a href=\"https:\/\/medicalxpress.com\/tags\/prostate+cancers\/\" rel=\"tag\" class=\"\">prostate cancers<\/a>, which often develop at a young age. In the clinic, these cancers are treated with a drug that inhibits PARP, another protein needed for DNA repair.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new paper published today in Nature, researchers at the Francis Crick Institute have outlined the structure and function of a protein complex that is required to repair damaged DNA and protect against cancer. Every time a cell replicates, mistakes can happen in the form of mutations, but specialized proteins exist to repair the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-166482","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=166482"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166482\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=166482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=166482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=166482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}