{"id":166167,"date":"2023-06-21T16:18:45","date_gmt":"2023-06-21T21:18:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/06\/a-new-tool-to-study-complex-genome-interactions"},"modified":"2023-06-21T16:18:45","modified_gmt":"2023-06-21T21:18:45","slug":"a-new-tool-to-study-complex-genome-interactions","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/06\/a-new-tool-to-study-complex-genome-interactions","title":{"rendered":"A new tool to study complex genome interactions"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-new-tool-to-study-complex-genome-interactions2.jpg\"><\/a><\/p>\n<p>People who owned black-and-white television sets until the 1980s didn\u2019t know what they were missing until they got a color TV. A similar switch could happen in the world of genomics as researchers at the Berlin Institute of Medical Systems Biology of the Max Delbr\u00fcck Center (MDC-BIMSB) have developed a technique called Genome Architecture Mapping (\u201cGAM\u201d) to peer into the genome and see it in glorious technicolor. GAM reveals information about the genome\u2019s spatial architecture that is invisible to scientists using solely Hi-C, a workhorse tool developed in 2009 to study DNA interactions, reports a new study in <i><i>Nature<\/i> Methods<\/i> by the Pombo lab.<\/p>\n<p>\u201cWith a black-and-white TV, you can see the shapes but everything looks gray,\u201d says Professor Ana Pombo, a <a href=\"https:\/\/phys.org\/tags\/molecular+biologist\/\" rel=\"tag\" class=\"\">molecular biologist<\/a> and head of the Epigenetic Regulation and Chromatin Architecture lab. \u201cBut if you have a color TV and look at flowers, you realize that they are red, yellow and white and we were unaware of it. Similarly, there\u2019s also information in the way the genome is folded in three-dimensions that we have not been aware of.\u201d<\/p>\n<p>Understanding DNA organization can reveal the basis of health and disease. Our cells pack a 2-meter-long genome into a roughly 10 micrometer-diameter nucleus. The packaging is done precisely so that regulatory DNA comes in contact with the right genes at the right times and turns them on and off. Changes to the three-dimensional configuration can disrupt this process and cause disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>People who owned black-and-white television sets until the 1980s didn\u2019t know what they were missing until they got a color TV. A similar switch could happen in the world of genomics as researchers at the Berlin Institute of Medical Systems Biology of the Max Delbr\u00fcck Center (MDC-BIMSB) have developed a technique called Genome Architecture Mapping [\u2026]<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-166167","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=166167"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/166167\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=166167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=166167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=166167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}