{"id":165851,"date":"2023-06-16T01:23:17","date_gmt":"2023-06-16T06:23:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/06\/psilocybin-induces-rapid-and-persistent-growth-of-dendritic-spines-in-frontal-cortex-in-vivo"},"modified":"2023-06-16T01:23:17","modified_gmt":"2023-06-16T06:23:17","slug":"psilocybin-induces-rapid-and-persistent-growth-of-dendritic-spines-in-frontal-cortex-in-vivo","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/06\/psilocybin-induces-rapid-and-persistent-growth-of-dendritic-spines-in-frontal-cortex-in-vivo","title":{"rendered":"Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/psilocybin-induces-rapid-and-persistent-growth-of-dendritic-spines-in-frontal-cortex-in-vivo3.jpg\"><\/a><\/p>\n<p>Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and timescale of the impact in a mammalian brain are unknown. In this study, we used chronic two-photon microscopy to image longitudinally the apical dendritic spines of layer 5 pyramidal neurons in the mouse medial frontal cortex. We found that a single dose of psilocybin led to \u223c10% increases in spine size and density, driven by an elevated spine formation rate. The structural remodeling occurred quickly within 24 h and was persistent 1 month later. Psilocybin also ameliorated stress-related behavioral deficit and elevated excitatory neurotransmission. Overall, the results demonstrate that psilocybin-evoked synaptic rewiring in the cortex is fast and enduring, potentially providing a structural trace for long-term integration of experiences and lasting beneficial actions.<\/p>\n<hr>\n<p>Psilocybin is a classical psychedelic that shows promise as a treatment for depression. Shao et al. show that psilocybin administration leads to long-lasting modifications to the neural architecture in mice. The increases in the density and strength of neuronal connections may underlie the enduring behavioral effects of the compound.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural adaptations, although the extent and timescale of the impact in a mammalian brain are unknown. In this study, we used chronic two-photon microscopy to image longitudinally the apical dendritic spines of layer 5 pyramidal neurons [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-165851","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/165851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=165851"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/165851\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=165851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=165851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=165851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}