{"id":165316,"date":"2023-06-07T13:27:50","date_gmt":"2023-06-07T18:27:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/06\/engineered-liver-on-a-chip-platform-to-mimic-liver-functions-and-its-biomedical-applications-a-review"},"modified":"2023-06-07T13:27:50","modified_gmt":"2023-06-07T18:27:50","slug":"engineered-liver-on-a-chip-platform-to-mimic-liver-functions-and-its-biomedical-applications-a-review","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/06\/engineered-liver-on-a-chip-platform-to-mimic-liver-functions-and-its-biomedical-applications-a-review","title":{"rendered":"Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-liver-on-a-chip-platform-to-mimic-liver-functions-and-its-biomedical-applications-a-review.jpg\"><\/a><\/p>\n<p>Year 2019 \ud83d\ude17\ud83d\ude01<\/p>\n<hr>\n<p>Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Year 2019 \ud83d\ude17\ud83d\ude01 Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,1523,38],"tags":[],"class_list":["post-165316","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-computing","category-engineering"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/165316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=165316"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/165316\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=165316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=165316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=165316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}