{"id":164004,"date":"2023-05-16T10:23:48","date_gmt":"2023-05-16T15:23:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/05\/artificial-intelligence-identifies-anti-aging-drug-candidates-targeting-zombie-cells"},"modified":"2023-05-16T10:23:48","modified_gmt":"2023-05-16T15:23:48","slug":"artificial-intelligence-identifies-anti-aging-drug-candidates-targeting-zombie-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/05\/artificial-intelligence-identifies-anti-aging-drug-candidates-targeting-zombie-cells","title":{"rendered":"Artificial intelligence identifies anti-aging drug candidates targeting \u2018zombie\u2019 cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/artificial-intelligence-identifies-anti-aging-drug-candidates-targeting-zombie-cells.jpg\"><\/a><\/p>\n<p>A new publication in the May issue of <i>Nature Aging<\/i> by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.<\/p>\n<p>The paper, \u201cDiscovering small-molecule senolytics with <a href=\"https:\/\/phys.org\/tags\/deep+neural+networks\/\" rel=\"tag\" class=\"\">deep neural networks<\/a>,\u201d authored in collaboration with researchers from the Massachusetts Institute of Technology (MIT) and the Broad Institute of MIT and Harvard, describes the AI-guided screening of more than 800,000 compounds to reveal three <a href=\"https:\/\/phys.org\/tags\/drug+candidates\/\" rel=\"tag\" class=\"\">drug candidates<\/a> with comparable efficacy and superior medicinal chemistry properties than those of senolytics currently under investigation.<\/p>\n<p>\u201cThis research result is a <a href=\"https:\/\/phys.org\/tags\/significant+milestone\/\" rel=\"tag\" class=\"\">significant milestone<\/a> for both longevity research and the application of artificial intelligence to <a href=\"https:\/\/phys.org\/tags\/drug+discovery\/\" rel=\"tag\" class=\"\">drug discovery<\/a>,\u201d said Felix Wong, Ph.D., co-founder of Integrated Biosciences and first author of the publication. \u201cThese data demonstrate that we can explore chemical space in silico and emerge with multiple candidate anti-aging compounds that are more likely to succeed in the clinic, compared to even the most promising examples of their kind being studied today.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,269,6],"tags":[],"class_list":["post-164004","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-life-extension","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/164004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=164004"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/164004\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=164004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=164004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=164004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}