{"id":163527,"date":"2023-05-08T10:24:30","date_gmt":"2023-05-08T15:24:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/05\/using-nanopore-single-molecule-sensing-to-identify-glycans"},"modified":"2023-05-08T10:24:30","modified_gmt":"2023-05-08T15:24:30","slug":"using-nanopore-single-molecule-sensing-to-identify-glycans","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/05\/using-nanopore-single-molecule-sensing-to-identify-glycans","title":{"rendered":"Using nanopore single-molecule sensing to identify glycans"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/using-nanopore-single-molecule-sensing-to-identify-glycans2.jpg\"><\/a><\/p>\n<p>Glycans perform varied and crucial functions in numerous cellular activities. The diverse roles of glycans are matched by their highly complex structures, which derive from differences in composition, branching, regio-and stereochemistry, and modification. This incomparable structural diversity is challenging to the structural analysis of glycans.<\/p>\n<p>Recently, a joint research group led by Prof. Qing Guangyan and Prof. Liang Xinmiao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a <a href=\"https:\/\/phys.org\/tags\/glycan\/\" rel=\"tag\" class=\"\">glycan<\/a> identification method based on <a href=\"https:\/\/phys.org\/tags\/nanopore\/\" rel=\"tag\" class=\"\">nanopore<\/a> single-molecule sensing through a glycan derivatization strategy. The study was published in <i>Nature Communications<\/i> on March 28.<\/p>\n<p>Identifying and sequencing glycans using nanopore single-molecule techniques has sparked interest; however, it has achieved little progress over the past dozen years. Only a handful of cases that focused on either high molecular weight polysaccharides or some monosaccharides were reported.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glycans perform varied and crucial functions in numerous cellular activities. The diverse roles of glycans are matched by their highly complex structures, which derive from differences in composition, branching, regio-and stereochemistry, and modification. This incomparable structural diversity is challenging to the structural analysis of glycans. Recently, a joint research group led by Prof. Qing Guangyan [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,219],"tags":[],"class_list":["post-163527","post","type-post","status-publish","format-standard","hentry","category-chemistry","category-physics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=163527"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163527\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=163527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=163527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=163527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}