{"id":163289,"date":"2023-05-03T11:22:19","date_gmt":"2023-05-03T16:22:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/05\/chemotherapy-drug-reaches-brain-in-humans-for-first-time"},"modified":"2023-05-03T11:22:19","modified_gmt":"2023-05-03T16:22:19","slug":"chemotherapy-drug-reaches-brain-in-humans-for-first-time","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/05\/chemotherapy-drug-reaches-brain-in-humans-for-first-time","title":{"rendered":"Chemotherapy drug reaches brain in humans for first time"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/KSDhqhKL-JQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>A major impediment to treating the deadly brain cancer glioblastoma has been that the most potent chemotherapy can\u2019t permeate the blood-brain barrier to reach the aggressive brain tumor.<\/p>\n<p>But now Northwestern Medicine scientists report results of the first in-human clinical trial in which they used a novel, skull-implantable ultrasound device to open the <a href=\"https:\/\/medicalxpress.com\/tags\/blood-brain+barrier\/\" rel=\"tag\" class=\"\">blood-brain barrier<\/a> and repeatedly permeate large, critical regions of the <a href=\"https:\/\/medicalxpress.com\/tags\/human+brain\/\" rel=\"tag\" class=\"\">human brain<\/a> to deliver chemotherapy that was injected intravenously.<\/p>\n<p>The four-minute procedure to open the blood-brain barrier is performed with the patient awake, and patients go home after a few hours. The results show the treatment is safe and well tolerated, with some patients getting up to six cycles of treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A major impediment to treating the deadly brain cancer glioblastoma has been that the most potent chemotherapy can\u2019t permeate the blood-brain barrier to reach the aggressive brain tumor. But now Northwestern Medicine scientists report results of the first in-human clinical trial in which they used a novel, skull-implantable ultrasound device to open the blood-brain barrier [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-163289","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=163289"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163289\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=163289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=163289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=163289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}