{"id":163168,"date":"2023-05-01T21:23:08","date_gmt":"2023-05-02T02:23:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/05\/researchers-uncover-new-clues-to-origins-of-the-most-common-pediatric-kidney-cancer"},"modified":"2023-05-01T21:23:08","modified_gmt":"2023-05-02T02:23:08","slug":"researchers-uncover-new-clues-to-origins-of-the-most-common-pediatric-kidney-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/05\/researchers-uncover-new-clues-to-origins-of-the-most-common-pediatric-kidney-cancer","title":{"rendered":"Researchers uncover new clues to origins of the most common pediatric kidney cancer"},"content":{"rendered":"

<\/a><\/p>\n

While Wilms tumor\u2014also known as nephroblastoma\u2014is rare, it is the most prevalent childhood kidney cancer. Researchers at Children\u2019s Hospital Los Angeles have now pinpointed a disruption in early kidney progenitor cell development that can be linked to the formation of Wilms tumor.<\/p>\n

In a study published in Advanced Science<\/i>, researchers at the GOFARR Laboratory in Urology compared kidney progenitor cells from a tumor<\/a> with precursor cells<\/a> from a healthy kidney. Normally, these precursor cells mature into kidney cells, but when their early development is dysregulated, they behave like cancer stem cells<\/a>.<\/p>\n

While most children with Wilms tumor are successfully treated, current therapies are aggressive. A minority of these patients have unfavorable prognoses or relapses; for these children, there is no existing therapy. \u201cBy achieving a more precise understanding of how Wilms tumors develop, our goal is to find new treatments for all types of Wilms tumor,\u201d says Laura Perin, Ph.D., Co-Director of the GOFARR laboratory and senior study co-author with Stefano Da Sacco, Ph.D., another researcher at the GOFARR Laboratory.<\/p>\n","protected":false},"excerpt":{"rendered":"

While Wilms tumor\u2014also known as nephroblastoma\u2014is rare, it is the most prevalent childhood kidney cancer. Researchers at Children\u2019s Hospital Los Angeles have now pinpointed a disruption in early kidney progenitor cell development that can be linked to the formation of Wilms tumor. In a study published in Advanced Science, researchers at the GOFARR Laboratory in [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-163168","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=163168"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/163168\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=163168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=163168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=163168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}