{"id":162643,"date":"2023-04-22T14:23:48","date_gmt":"2023-04-22T19:23:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/study-points-to-new-approach-to-treat-chronic-transplant-rejection"},"modified":"2023-04-22T14:23:48","modified_gmt":"2023-04-22T19:23:48","slug":"study-points-to-new-approach-to-treat-chronic-transplant-rejection","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/study-points-to-new-approach-to-treat-chronic-transplant-rejection","title":{"rendered":"Study points to new approach to treat chronic transplant rejection"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-points-to-new-approach-to-treat-chronic-transplant-rejection2.jpg\"><\/a><\/p>\n<p>University of Pittsburgh researchers have identified a type of immune cell that drives chronic organ transplant failure in a mouse model of kidney transplantation and uncovered pathways that could be therapeutically targeted to improve patient outcomes. The findings are published in a new <i>Science Immunology<\/i> paper.<\/p>\n<p>\u201cIn solid organ transplantation, such as kidney transplants, one-year outcomes are excellent because we have immunosuppressant drugs that manage the problem of acute rejection,\u201d said co-senior author Fadi Lakkis, M.D., distinguished professor of surgery, professor of immunology and medicine, and scientific director of the Thomas E. Starzl Transplantation Institute at Pitt and UPMC.<\/p>\n<p>\u201cBut over time, these organs often start to fail because of a slower form of rejection called chronic rejection, and current medications don\u2019t seem to help. Understanding this problem was the motivation behind our study.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Pittsburgh researchers have identified a type of immune cell that drives chronic organ transplant failure in a mouse model of kidney transplantation and uncovered pathways that could be therapeutically targeted to improve patient outcomes. The findings are published in a new Science Immunology paper. \u201cIn solid organ transplantation, such as kidney transplants, one-year [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-162643","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=162643"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162643\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=162643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=162643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=162643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}