{"id":162198,"date":"2023-04-14T22:22:43","date_gmt":"2023-04-15T03:22:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2023\/04\/nf-%ce%bab-decoy-odn-loaded-polylactic-co-glycolic-acid-nanospheres-inhibit-alveolar-ridge-resorption"},"modified":"2023-04-14T22:22:43","modified_gmt":"2023-04-15T03:22:43","slug":"nf-%ce%bab-decoy-odn-loaded-polylactic-co-glycolic-acid-nanospheres-inhibit-alveolar-ridge-resorption","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2023\/04\/nf-%ce%bab-decoy-odn-loaded-polylactic-co-glycolic-acid-nanospheres-inhibit-alveolar-ridge-resorption","title":{"rendered":"NF-\u03baB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nf-cebab-decoy-odn-loaded-polylactic-co-glycolic-acid-nanospheres-inhibit-alveolar-ridge-resorption.jpg\"><\/a><\/p>\n<p>Residual ridge resorption combined with dimensional loss resulting from tooth extraction has a prolonged correlation with early excessive inflammation. Nuclear factor-kappa B (NF-\u03baB) decoy oligodeoxynucleotides (ODNs) are double-stranded DNA sequences capable of downregulating the expression of downstream genes of the NF-\u03baB pathway, which is recognized for regulating prototypical proinflammatory signals, physiological bone metabolism, pathologic bone destruction, and bone regeneration. The aim of this study was to investigate the therapeutic effect of NF-\u03baB decoy ODNs on the extraction sockets of Wistar\/ST rats when delivered by poly(lactic-co-glycolic acid) (PLGA) nanospheres.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Residual ridge resorption combined with dimensional loss resulting from tooth extraction has a prolonged correlation with early excessive inflammation. Nuclear factor-kappa B (NF-\u03baB) decoy oligodeoxynucleotides (ODNs) are double-stranded DNA sequences capable of downregulating the expression of downstream genes of the NF-\u03baB pathway, which is recognized for regulating prototypical proinflammatory signals, physiological bone metabolism, pathologic bone [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-162198","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=162198"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/162198\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=162198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=162198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=162198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}